Evidence map›Paper›PMID 28654417›Full record

ArticleMolecular imaging2016

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [

Dragana Savic, Valentina Pedoia, Youngho Seo, Jaewon Yang, Matt Bucknor, Benjamin L Franc, Sharmila Majumdar

Registry-linked trialAbstract read
In one paragraph

Article in Molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03949127 (Efficacy of a Non-surgical Treatment Protocol for Patients With Symptomatic Femoro-acetabular Impingement), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03949127 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of a Non-surgical Treatment Protocol for Patients With Symptomatic Femoro-acetabular Impingement: a Randomized Controlled Trial

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2019 to 2024Enrolled95ConditionsFemoracetabular ImpingementArmsExercise Group
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Validation of quantitative [Annals of nuclear medicine · 2025
    Pooled it
  2. Pooled it
  3. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. European journal of nuclear medicine and molecular imaging · 2023
    Article
  11. Article
  12. [Osteoarthritis and cartilage · 2022
    Article
  13. Imaging joint infections using D-methyl-European journal of nuclear medicine and molecular imaging · 2022
    Article
  14. Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Assessment of quantitative [Osteoarthritis and cartilage · 2021
    Article
  19. Review
  20. [Frontiers in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dragana Savic1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Valentina Pedoia1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Youngho Seo1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Jaewon Yang1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Matt Bucknor1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Benjamin L Franc1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Sharmila Majumdar1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.

Funding

UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
NIAMS NIH HHS P30 AR066262
6 · The paper itself

Abstract

purposeSimultaneous positron emission tomography-magnetic resonance imaging (PET-MRI) is an emerging technology providing both anatomical and functional images without increasing the scan time. Compared to the traditional PET/computed tomography imaging, it also exposes the patient to significantly less radiation and provides better anatomical images as MRI provides superior soft tissue characterization. Using PET-MRI, we aim to study interactions between cartilage composition and bone function simultaneously, in knee osteoarthritis (OA). PROCEDURES: In this article, bone turnover and remodeling was studied using [

resultsIncreases in cartilage T

conclusionThis study shows significant cartilage and bone interactions in OA of the knee joint using simultaneous [

Indexed as

Bone and BonesBone RemodelingCartilageFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMolecular ImagingOsteoarthritis, KneePositron-Emission TomographySodium FluorideSodium Fluoridebone–cartilage interactionsbone remodelingcartilage degenerationknee osteoarthritismultimodality imagingPET-MRIsodium fluoride imagingT1ρ relaxation timesvoxel-by-voxel statistical parameter mapping

Identifiers

PMID28654417
PMCPMC5470142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.