Evidence map›Paper›PMID 28654363›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017

Low-Fat Dietary Pattern and Breast Cancer Mortality in the Women's Health Initiative Randomized Controlled Trial.

Rowan T Chlebowski, Aaron K Aragaki, Garnet L Anderson, Cynthia A Thomson, JoAnn E Manson, Michael S Simon, Barbara V Howard, Thomas E Rohan, Linda Snetselar, Dorothy Lane and 7 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 6 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Trial
  8. Trial
  9. Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women's Health Initiative Randomized Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Trial
  10. Trial
  11. Trial
  12. Review
  13. Review
  14. Diet and Chronic Disease Research in the Women's Health Initiative.Journal of the Academy of Nutrition and Dietetics · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Rowan T ChlebowskiRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Aaron K AragakiRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Garnet L AndersonRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Cynthia A ThomsonRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
JoAnn E MansonRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Michael S SimonRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Barbara V HowardRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Thomas E RohanRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Linda SnetselarRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Dorothy LaneRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Wendy BarringtonRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Mara Z VitolinsRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Catherine WomackRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Lihong QiRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Lifang HouRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Fridtjof ThomasRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Ross L PrenticeRowan T. Chlebowski, Los Angeles Biomedical Research Institute, Torrance; Lihong Qi, University of California, Davis, Davis, CA; Aaron K. Aragaki, Garnet L. Anderson, Wendy Barrington, and Ross L. Prentice, Fred Hutchinson Cancer Research Center, Seattle, WA; Cynthia A. Thomson, University of Arizona Cancer Center, Tucson, AZ; JoAnn E. Manson, Brigham and Women's Hospital, Boston, MA; Michael S. Simon, Wayne State University, Detroit, MI; Barbara V. Howard, MedStar Health Research Institute; Barbara V. Howard, Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC; Thomas E. Rohan, Albert Einstein College of Medicine, New York City; Dorothy Lane, Stony Brook University, Stony Brook, NY; Linda Snetselar, University of Iowa, Iowa City, IA; Catherine Womack, Methodist Healthcare; Fridtjof Thomas, University of Tennessee Health Science Center, Memphis, TN; Mara Z. Vitolins, Wake Forest School of Medicine, Winston-Salem, NC; and Lifang Hou, Northwestern University, Chicago, IL.
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZA

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Women's Health Initiative Cancer Survivor CohortUM1CA173642 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L., CAAN, BETTE J · 2013 to 2018
$12.1M
Use of Biomarkers in Diagnosis, Prognosis, Risk Prediction and Early Detection ofP01CA053996 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI FENG, ZIDING · 1991 to 2015
$9.4M
Life and Longevity After Cancer (LILAC): The Women's Health Initiative Cancer Survivor CohortU01CA173642 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L., PASKETT, ELECTRA D. · 2019 to 2023
$7.5M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
Statistical Methods for Multivariate Failure Time DataR01CA210921 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRENTICE, ROSS L · 2017 to 2018
$329k
NCATS NIH HHS UL1 TR001409NCI NIH HHS P01 CA053996NCI NIH HHS R01 CA210921NCI NIH HHS U01 CA173642NCI NIH HHS UM1 CA173642WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Purpose Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of follow-up. Patients and Methods The trial randomly assigned 48,835 postmenopausal women with normal mammograms and without prior breast cancer from 1993 to 1998 at 40 US clinical centers to a dietary intervention with goals of a reduction of fat intake to 20% of energy and an increased intake of fruits, vegetables, and grains (40%; n = 19,541) or to a usual diet comparison (60%; n = 29,294). Results In the dietary group, fat intake and body weight decreased (all P < .001). During the 8.5-year dietary intervention, with 1,764 incident breast cancers, fewer deaths occurred as a result of breast cancer in the dietary group, which was not statistically significant (27 deaths [0.016% per year] v 61 deaths [0.024% per year]; hazard ratio [HR], 0.67; 95% CI, 0.43 to 1.06; P = .08). During the same period, deaths after breast cancer (n = 134) were significantly reduced (40 deaths [0.025% per year] v 94 deaths [0.038% per year]; HR, 0.65; 95% CI, 0.45 to 0.94; P = .02) by the dietary intervention. During the 16.1-year follow-up, with 3,030 incident breast cancers, deaths after breast cancer also were significantly reduced (234 deaths [0.085% per year] v 443 deaths [0.11% per year]; HR, 0.82; 95% CI, 0.70 to 0.96; P = .01) in the dietary group. Conclusion Compared with a usual diet comparison group, a low-fat dietary pattern led to a lower incidence of deaths after breast cancer.

Indexed as

AgedBreast NeoplasmsDiet, Fat-RestrictedFemaleHumansMiddle AgedPostmenopauseUnited StatesWomen's Health

Identifiers

PMID28654363
PMCPMC5578391
OpenAlexW2726257318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.