ArticleMolecular nutrition & food research2017
High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression.
Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Unraveling the Diet-Learning Nexus: a cross-sectional deep dive into Iranian adolescents' nutrient patterns and learning difficulties.BMC nutrition · 2026Article
- The Relationship Between Dietary Sodium Intake and Cognitive Function: A Narrative Review.Current nutrition reports · 2026Review
- Association of Healthy Eating Index-2020 scores and its components with epilepsy in US adults: a cross-sectional study of NHANES 2005-2020.BMC neurology · 2026Article
- Gut microbiota dysbiosis is associated with hippocampal neuronal damage and behavioral alterations in APP/PS1 mice with high-salt diet.Frontiers in microbiology · 2026Article
- Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Investigating the protective effect of hydroxylated fullerenes on cognitive function in rats with temporal lobe epilepsy.Scientific reports · 2025Article
- Dietary salt, vascular dysfunction, and cognitive impairment.Cardiovascular research · 2025Review
- Review
- Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study.Genes & nutrition · 2024Article
- Investigating the Potential Anti-Alzheimer's Disease Mechanism of Marine Polyphenols: Insights from Network Pharmacology and Molecular Docking.Marine drugs · 2023Article
- Article
- A high-salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice.iMeta · 2023Article
- Article
- The impact of a high-sodium diet regimen on cerebrovascular morphology and cerebral perfusion in Alzheimer's disease.Cerebral circulation - cognition and behavior · 2023Article
- Alterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet.International journal of molecular sciences · 2022Article
- Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.Aging and disease · 2022Article
- High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes.Nutrients · 2021Article
- The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?Cell stress & chaperones · 2021Review
- High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
scopeA high salt (HS) diet is detrimental to cognitive function, in addition to having a role in cardiovascular disorders. However, the method by which an HS diet impairs cognitive functions such as learning and memory remains open. METHODS AND
resultsIn this study, we found that mice on a 7 week HS diet demonstrated disturbed short-term memory in an object-place recognition task, and both 4 week and 7 week HS treatments impaired long-term memory, as evidenced in a fear conditioning test. Mechanistically, the HS diet inhibited memory-related long-term potentiation (LTP) in the hippocampus, while also increasing the levels of reactive oxygen species (ROS) in hippocampal cells and downregulating the expression of synapsin I, synaptophysin, and brain-derived neurotrophic factor in specific encephalic region.
conclusionThis suggests that oxidative stress or synaptic protein/neurotrophin deregulation was involved in the HS diet-induced memory impairment. Thus, the present study provides novel insights into the mechanisms of memory impairment caused by excessive dietary salt, and underlined the importance of controlling to salt absorb quantity.
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