Evidence map›Paper›PMID 28654093›Full record

ArticleTranslational psychiatry2017

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders.

P-F Kuan, M A Waszczuk, R Kotov, C J Marsit, G Guffanti, A Gonzalez, X Yang, K Koenen, E Bromet, B J Luft

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 8 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 8 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

P-F KuanDepartment of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
M A WaszczukDepartment of Psychiatry, Stony Book University, Stony Brook, NY, USA.
R KotovDepartment of Psychiatry, Stony Book University, Stony Brook, NY, USA.
C J MarsitDepartment of Environmental Health, Emory University, Atlanta, GA, USA.
G GuffantiNeurobiology of Fear Laboratory, McLean Hospital, Harvard Medical School, Boston, MA, USA.
A GonzalezDepartment of Psychiatry, Stony Book University, Stony Brook, NY, USA.
X YangDepartment of Psychiatry, Stony Book University, Stony Brook, NY, USA.
K KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
E BrometDepartment of Psychiatry, Stony Book University, Stony Brook, NY, USA.
B J LuftDepartment of Medicine, Stony Brook University, Stony Brook, NY, USA.
Stony Brook University · USEmory University · USHarvard University · USMcLean Hospital · US

Funding

Epigenetic Linkage Between PTSD and Respiratory Disease in WTC RespondersU01OH010416 · OH · STATE UNIVERSITY NEW YORK STONY BROOK · PI LUFT, BENJAMIN J · 2012 to 2013
$1000k
NIOSH CDC HHS U01 OH010416
6 · The paper itself

Abstract

Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to small sample sizes, and measurement and tissue differences. The current two EWA analyses of 473 World Trade Center responders are the largest to date for both PTSD and MDD. These analyses investigated DNA methylation patterns and biological pathways influenced by differentially methylated genes associated with each disorder. Methylation was profiled on blood samples using Illumina 450 K Beadchip. Two EWA analyses compared current versus never PTSD, and current versus never MDD, adjusting for cell types and demographic confounders. Pathway and gene set enrichment analyses were performed to understand the complex biological systems of PTSD and MDD. No significant epigenome-wide associations were found for PTSD or MDD at an FDR P<0.05. The majority of genes with differential methylation at a suggestive threshold did not overlap between the two disorders. Pathways significant in PTSD included a regulator of synaptic plasticity, oxytocin signaling, cholinergic synapse and inflammatory disease pathways, while only phosphatidylinositol signaling and cell cycle pathways emerged in MDD. The failure of the current EWA analyses to detect significant epigenome-wide associations is in contrast with disparate findings from previous, smaller EWA and candidate gene studies of PTSD and MDD. Enriched gene sets involved in several biological pathways, including stress response, inflammation and physical health, were identified in PTSD, supporting the view that multiple genes play a role in this complex disorder.

Indexed as

DNA MethylationEmergency RespondersEpigenesis, GeneticSeptember 11 Terrorist AttacksCpG IslandsEpigenomicsGenome-Wide Association StudyHumansMajor Depressive DisorderMaleMiddle AgedSignal TransductionStress Disorders, Post-Traumatic

Identifiers

PMID28654093
PMCPMC5537648
OpenAlexW2634894186

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.