ArticleJournal of visualized experiments : JoVE2017
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury.
Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Peripheral macrophages and T-cells accumulate in the degenerating optic tract after repetitive head impact.Brain, behavior, and immunity · 2026Article
- High-Precision Pneumatic Induction of Traumatic Brain Injury in Larval Zebrafish.bioRxiv : the preprint server for biology · 2026Article
- High frequency head impact exposure changes hippocampal sharp-wave ripple architecture.PloS one · 2026Article
- Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury.Inflammopharmacology · 2025Article
- Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice.Neurotrauma reports · 2025Article
- Amnesia after Repeated Head Impact Is Caused by Impaired Synaptic Plasticity in the Memory Engram.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- High-Frequency Head Impact Disrupts Hippocampal Neural Ensemble Dynamics.Frontiers in cellular neuroscience · 2021Article
- Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury.Frontiers in neurology · 2020Review
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mild Traumatic Brain Injury (mTBI) can result in the acute loss of brain function, including a period of confusion, a loss of consciousness (LOC), focal neurological deficits and even amnesia. Athletes participating in contact sports are at high risk of exposure to large number of mTBIs. In terms of the level of injury in a sporting athlete, a mTBI is defined as a mild injury that does not cause gross pathological changes, but does cause short-term neurological deficits that are spontaneously resolved. Despite previous attempts to model mTBI in mice and rats, many have reported gross adverse effects including skull fractures, intracerebral bleeding, axonal injury and neuronal cell death. Herein, we describe our highly reproducible animal model of mTBI that reproduces clinically relevant symptoms. This model uses a custom made pneumatic impactor device to deliver a closed-head trauma. This impact is made under precise velocity and deformation parameters, creating a reliable and reproducible model to examine the mechanisms that contribute to effects of single or repetitive concussive mTBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.