Evidence map›Paper›PMID 28654063›Full record

ArticleJournal of visualized experiments : JoVE2017

A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice.

Xiangbing Wu, Yi Ping Zhang, Wenrui Qu, Lisa B E Shields, Christopher B Shields, Xiao-Ming Xu

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Xiangbing WuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine, Indiana University School of Medicine.
Yi Ping ZhangNorton Neuroscience Institute, Norton Healthcare.
Wenrui QuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine, Indiana University School of Medicine.
Lisa B E ShieldsNorton Neuroscience Institute, Norton Healthcare.
Christopher B ShieldsNorton Neuroscience Institute, Norton Healthcare; Department of Anatomical Sciences and Neurobiology, University of Louisville; cbshields1@gmail.com.
Xiao-Ming XuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine, Indiana University School of Medicine; xu26@iupui.edu.
Indiana University School of MedicineNorton Healthcare · USNeurological Surgery · USUniversity of Louisville · US

Funding

Role of phospholipase A2 in spinal cord secondary injuryR01NS059622 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI XU, XIAO-MING · 2009 to 2013
$1.6M
Role of Acrolein in Spinal Cord InjuryR01NS073636 · NINDS · PURDUE UNIVERSITY · PI SHI, RIYI · 2012 to 2015
$1.4M
Constructing a growth-promoting pathway for functional regeneration after SCII01BX002356 · VA · RLR VA MEDICAL CENTER · PI BROWN, TODD J, JONES, KATHRYN JANE · 2015 to 2023
–
BLRD VA I01 BX002356NINDS NIH HHS R01 NS059622NINDS NIH HHS R01 NS073636
6 · The paper itself

Abstract

Producing a consistent and reproducible contusive spinal cord injury (SCI) is critical to minimizing behavioral and histological variabilities between experimental animals. Several contusive SCI models have been developed to produce injuries using different mechanisms. The severity of the SCI is based on the height that a given weight is dropped, the injury force, or the spinal cord displacement. In the current study, we introduce a novel mouse contusive SCI device, the Louisville Injury System Apparatus (LISA) impactor, which can create a displacement-based SCI with high injury velocity and accuracy. This system utilizes laser distance sensors combined with advanced software to produce graded and highly-reproducible injuries. We performed a contusive SCI at the 10

Indexed as

Disease Models, AnimalEquipment DesignAnimalsFemaleLaminectomyMiceMice, Inbred C57BLRecovery of FunctionSpinal CordSpinal Cord Injuries

Identifiers

PMID28654063
PMCPMC5608444
OpenAlexW2625737756

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.