Trial reportNutrients2017
Preventive Effect of Cow's Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multicenter Randomized Controlled Trial.
Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 9 pooled it
7.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 9 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Strain-Specific Effects of Early-Life Probiotic Supplementation on Respiratory Infections in Infants: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- Comparative efficacy of different probiotic strains and preparations for prevention of acute otitis media in children: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- The effect of bovine dairy products and their components on the incidence and natural history of infection: a systematic literature review.Nutrition journal · 2024Pooled it
- Effects of probiotics on the prevention and treatment of children with allergic rhinitis: a meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2024Pooled it
- Validity of food additive maltodextrin as placebo and effects on human gut physiology: systematic review of placebo-controlled clinical trials.European journal of nutrition · 2022Pooled it
- Probiotics for preventing acute upper respiratory tract infections.The Cochrane database of systematic reviews · 2022Pooled it
- Effect of probiotic fermented dairy products on incidence of respiratory tract infections: a systematic review and meta-analysis of randomized clinical trials.Nutrition journal · 2021Pooled it
- Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review.Nutrients · 2020Pooled it
- Probiotics for preventing acute otitis media in children.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of Heat-TreatedNutrients · 2024Trial
- Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Trial
- ProbioticNutrients · 2019Trial
- Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74.Applied and environmental microbiology · 2017Trial
- Trial
- Postbiotics: An Overview and Recommendations for Improved Reporting.Molecular nutrition & food research · 2026Review
- Impact of Fermented Dairy on Gastrointestinal Health and Associated Biomarkers.Nutrition reviews · 2026Review
- Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and Microbial Ecosystem Modulation.Microorganisms · 2026Review
- Novel approach to substantiate cause-and-effect relationships: combining study ranking and statistical modelling, with a crucial role of data sharing.European journal of nutrition · 2025Article
- Probiotic, Prebiotic, and Synbiotic Supplementation for the Prevention and Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- A Postbiotic Derived fromFoods (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Giovanni CorselloOperative Unit of Pediatrics and Neonatal Intensive Therapy, Mother and Child Department, University of Palermo, 90121 Palermo, Italy. giocors@alice.it.
Maurizio CartaOperative Unit of Pediatrics and Neonatal Intensive Therapy, Mother and Child Department, University of Palermo, 90121 Palermo, Italy. cxbn@unin.it.
Roberto MarinelloFederazione Italiana Medici Pediatri Lombardia, 46100 Mantova, Italy. hetht@unin.it.
Marina PiccaPediatric Society of Primary Health Care (SICuPP), 20135 Milan, Italy. dafnfhm@unin.it.
Giulio De MarcoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. gntm@unin.it.
Maria MicilloDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. csvbu@unin.it.
Dante FerraraDepartment of Sciences for Health Promotion and Mother and Child Care, University of Palermo, 90121 Palermo, Italy. uhvbu@unin.it.
Patrizia VigneriFamily Pediatrician, 90133 Palermo, Italy. vignerip@gmail.com.
Gaetano CecereDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. rtntm@unin.it.
Pasqualina FerriDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. ryhm@unin.it.
Paola RoggeroDepartment of Clinical Science and Community Health, Neonatal Intensive Care Unit, Fondazione I.R.C.C.S. Cà Granda Ospedale Maggiore Policlinico, University of Milan, 20143 Milan, Italy. sdvedd@unin.it.
Giorgio BedogniClinical Epidemiology Unit, Liver Research Center, Basovizza, 34012 Trieste, Italy. giorgiobedogni@gmail.com.
Fabio MoscaDepartment of Clinical Science and Community Health, Neonatal Intensive Care Unit, Fondazione I.R.C.C.S. Cà Granda Ospedale Maggiore Policlinico, University of Milan, 20143 Milan, Italy. fabio.mosca@mangiagalli.it.
Lorella PaparoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. paparolorella@gmail.com.
Rita NocerinoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. ritanocerino@alice.it.
Roberto Berni CananiDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II" Via S. Pansini, 5, 80131 Naples, Italy. berni@unina.it.
University of Naples Federico II · ITUniversity of Palermo · ITUniversity of Milan · ITAREA Science Park · ITCeinge Biotecnologie Avanzate (Italy) · ITItalian Society of Physiotherapy · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the efficacy of dietary supplementation with cow's skim milk fermented with the probiotic
Indexed as
Cultured Milk ProductsLacticaseibacillus paracaseiAnimalsAntimicrobial Cationic PeptidesCathelicidinsCattleChild, PreschoolCommunicable DiseasesDefensinsDouble-Blind MethodFecesFemaleFermentationGastroenteritisHumansImmunoglobulin AAntimicrobial Cationic PeptidesCathelicidinsDefensinsImmunoglobulin Aacquired immunityacute gastroenteritisgut microbiotaimmunonutritioninnate immunityprobioticsupper respiratory tract infections
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.