ArticleBipolar disorders2017
Longitudinal cognitive trajectories and associated clinical variables in youth with bipolar disorder.
Article in Bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Challenges and Opportunities in Using Cognitive Screeners for Adolescents and Young Adults With Bipolar Disorder.Focus (American Psychiatric Publishing) · 2025Article
- Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study.Frontiers in human neuroscience · 2025Article
- Identity state-dependent self-relevance and emotional intensity ratings of words in dissociative identity disorder: A controlled longitudinal study.Brain and behavior · 2023Article
- Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria.Annals of medicine · 2023Article
- Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder.European child & adolescent psychiatry · 2022Article
- Association of Lithium and Second-Generation Antipsychotics with Neurocognition in Youth with Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2022Article
- Cognitive profiles in bipolar I disorder and associated risk factors: Using Wechsler adult intelligence scale-IV.Frontiers in psychology · 2022Article
- What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence.Brain sciences · 2021Review
- Longitudinal course of depressive symptom severity among youths with bipolar disorders: Moderating influences of sustained attention and history of child maltreatment.Journal of affective disorders · 2021Article
- The Greater Houston Area Bipolar Registry-Clinical and Neurobiological Trajectories of Children and Adolescents With Bipolar Disorders and High-Risk Unaffected Offspring.Frontiers in psychiatry · 2021Article
- Monitoring neurocognitive functioning in childhood cancer survivors: evaluation of CogState computerized assessment and the Behavior Rating Inventory of Executive Function (BRIEF).BMC psychology · 2019Article
- Predictors of longitudinal psychosocial functioning in bipolar youth transitioning to adults.Journal of affective disorders · 2019Article
- Cortical inhibition in symptomatic and remitted mania compared to healthy subjects: A cross-sectional study.Bipolar disorders · 2017Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveThere is substantial interest in delineating the course of cognitive functioning in bipolar (BP) youth. However, there are no longitudinal studies aimed at defining subgroups of BP youth based on their distinctive cognitive trajectories and their associated clinical variables.
methodCognitive functioning was measured in 135 participants from the Course and Outcome of BP Youth (COBY) study using several subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Youth were prospectively evaluated three times on average every 13.75 months over 2.5 years. Clinical and functional outcomes were assessed using the Longitudinal Interval Follow-Up Evaluation (LIFE).
resultsLatent class growth analysis identified three longitudinal patterns of cognitive functioning based on a general cognitive index: class 1, "persistently high" (N=21; 15.6%); class 2, "persistently moderate" (N=82; 60.74%); and class 3, "persistently low" (N=32; 23.7%). All classes showed normal cognitive functioning when compared with the CANTAB normative data. After adjustment for confounders, youth from class 3 had a significantly greater percentage of time with overall, manic, and depressive syndromal symptoms than youth in the other two classes. Also, after adjustment for confounders, youth from class 3 had significantly poorer global, academic, and social functioning than youth from class 1.
conclusionsBP youth showed normal overall cognitive functioning that remained stable during the follow-up within each class. However, 24% of BP youth showed poorer cognitive functioning than the other BP youth. This subgroup had poorer mood course and functioning, and may benefit from cognitive remediation and early management with evidence-based pharmacological treatments.
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