SynthesisHuman brain mapping2017
Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis.
Synthesis in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Unraveling consistently altered brain activations of language deficits in schizophrenia: evidence from ALE meta-analysis.Translational psychiatry · 2025Pooled it
- Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms.Frontiers in psychiatry · 2024Pooled it
- Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder.Human brain mapping · 2021Pooled it
- The functional neural architecture of dysfunctional reward processing in autism.NeuroImage. Clinical · 2021Pooled it
- An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.Psychological medicine · 2020Pooled it
- Higher VOScientific reports · 2021Trial
- Nonverbal Communication Processing in Deaf Adults: An Activation Likelihood Estimation Meta-Analysis.Brain sciences · 2025Review
- Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach.Molecular psychiatry · 2025Article
- Differential structural cortical correlates of positive, negative, and linguistic control formal thought disorder dimensions in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Schizophasia and Cognitive Impairment in Schizophrenia: A Literature Review.Brain sciences · 2024Review
- Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset.Molecular psychiatry · 2024Article
- The Neurobiology of Formal Thought Disorder.Current topics in medicinal chemistry · 2024Review
- Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders-an fMRI pilot trial.Frontiers in psychiatry · 2024Article
- Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study.Research square · 2023Article
- Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.Schizophrenia bulletin · 2023Article
- Language Network Dysfunction and Formal Thought Disorder in Schizophrenia.Schizophrenia bulletin · 2023Review
- Grammatical impairment in schizophrenia: An exploratory study of the pronominal and sentential domains.PloS one · 2023Article
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- Association between aerobic fitness and the functional connectome in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Dimensions of Formal Thought Disorder and Their Relation to Gray- and White Matter Brain Structure in Affective and Psychotic Disorders.Schizophrenia bulletin · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Formal thought disorder (FTD) refers to a psychopathological dimension characterized by disorganized and incoherent speech. Whether symptoms of FTD arise from aberrant processing in language-related regions or more general cognitive networks, however, remains debated. Here, we addressed this question by a quantitative meta-analysis of published functional neuroimaging studies on FTD. The revised Activation Likelihood Estimation (ALE) algorithm was used to test for convergent aberrant activation changes in 18 studies (30 experiments) investigating FTD, of which 17 studies comprised schizophrenia patients and one study healthy subjects administered to S-ketamine. Additionally, we analyzed task-dependent and task-independent (resting-state) functional connectivity (FC) of brain regions showing convergence in activation changes. Subsequent functional characterization was performed for the initial clusters and the delineated connectivity networks by reference to the BrainMap database. Consistent activation changes were found in the left superior temporal gyrus (STG) and two regions within the left posterior middle temporal gyrus (p-MTG), ventrally (vp-MTG) and dorsally (dp-MTG). Functional characterization revealed a prominent functional association of ensuing clusters from our ALE meta-analysis with language and speech processing, as well as auditory perception in STG and with social cognition in dp-MTG. FC analysis identified task-dependent and task-independent networks for all three seed regions, which were mainly related to language and speech processing, but showed additional involvement in higher order cognitive functions. Our findings suggest that FTD is mainly characterized by abnormal activation in brain regions of the left hemisphere that are associated with language and speech processing, but also extend to higher order cognitive functions. Hum Brain Mapp 38:4946-4965, 2017. © 2017 Wiley Periodicals, Inc.
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