ArticleThe American journal of gastroenterology2017
Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025Article
- Appendectomy Is Not Associated With a Milder Clinical Course of Ulcerative Colitis: A Nationwide Danish Population-Based Study.Alimentary pharmacology & therapeutics · 2025Article
- Article
- The Place of Appendicectomy in Inflammatory Bowel Disease-A Review.ANZ journal of surgery · 2025Review
- Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children.BMC medicine · 2024Article
- Colonoscopy in the diagnosis and management of appendiceal disease.World journal of gastrointestinal endoscopy · 2024Article
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy - a cohort study.BMJ open gastroenterology · 2022Article
- Patients withWorld journal of gastrointestinal surgery · 2021Article
- State-of-the-art surgery for ulcerative colitis.Langenbeck's archives of surgery · 2021Article
- Cross Talk between Gut Microbiota and Intestinal Mucosal Immunity in the Development of Ulcerative Colitis.Infection and immunity · 2021Review
- Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.Mucosal immunology · 2021Review
- Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities.Frontiers in microbiology · 2021Article
- Ulcerative colitis.Nature reviews. Disease primers · 2020Review
- Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease.Digestive diseases and sciences · 2019Review
- Application of Big Data analysis in gastrointestinal research.World journal of gastroenterology · 2019Review
- Influence of Environmental Factors in the Development and Outcomes of Inflammatory Bowel Disease.Gastroenterology & hepatology · 2019Article
- Extensive Disease Subtypes in Adult Patients with Ulcerative Colitis: Non-pancolitis Versus Pancolitis.Digestive diseases and sciences · 2018Article
- Pathophysiology of the Appendix in Ulcerative Colitis.The American journal of gastroenterology · 2018Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesUlcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy. Appendectomy is associated with a lower risk of later developing UC. We aimed to assess the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients.
methodsA national cohort of UC patients with a diagnosis in 1964-2010 was identified from the Swedish National Patient Register that also provided information regarding appendicitis and/or appendectomy before or after the UC diagnosis. The risk for colectomy and UC-related hospital admissions was evaluated.
resultsAmong 63,711 UC patients, 2,143 had appendectomy and 7,690 underwent colectomy. Appendectomy for appendicitis before 20 years of age and for non-appendicitis at all ages before UC diagnosis was associated with a lower risk of colectomy (hazard ratio (HR) 0.44, 0.27-0.72 and HR 0.62, 0.43-0.90, respectively), and fewer hospital admissions (incidence rate ratio (IRR) 0.68, 95% confidence interval (CI) 0.64-0.73 and IRR 0.54, 0.47-0.63, respectively). Appendectomy for appendicitis after the UC diagnosis was associated with a higher risk of colectomy (HR 1.56, 1.20-2.03), whereas no such association was found for other pathology (HR 1.40, 0.79-2.47).
conclusionsAppendectomy early in life and before developing UC is associated with a lower risk of colectomy as well as UC-related hospital admissions. Appendectomy for appendicitis after established UC appears associated with a worse disease course, with an increased rate of subsequent colectomy.
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