A tail of translational regulation.

Open access · goldAbstract readComment

In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.2field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

OverexpressingMarine drugs · 2022
Article
Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging.Current cardiology reviews · 2022
Review
Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart.PloS one · 2022
Article
Large-scale tethered function assays identify factors that regulate mRNA stability and translation.Nature structural & molecular biology · 2020
Article
Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation.RNA (New York, N.Y.) · 2020
Article

4 · The record

Corrections and comments

Comment on
Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.2017

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gillian A GrayBHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-3104-3305

Nicola K GrayMRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-0413-1767

MRC Centre for Reproductive Health · GBThe Queen's Medical Research Institute · GB

Funding

Medical Research Council MC_U127692697Medical Research Council MR/J003069/1Medical Research Council MR/P02419X/1

6 · The paper itself

Abstract

An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.

Indexed as

Poly(A)-Binding Protein IRNA-Binding ProteinsHeartRNA, MessengerPoly(A)-Binding Protein IRNA-Binding ProteinsRNA, Messengerbiochemistrycardiac hypertrophydevelopmental biologymousepolyadenylationpostnatal heart developmentpost-transcriptional gene regulationprotein synthesisstem cellstranslation control

Identifiers

PMID28653621

DOI10.7554/eLife.29104

PMCPMC5487164

OpenAlexW2647510994

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.