Evidence map›Paper›PMID 28653322›Full record

ArticleAnnals of human genetics2017

Differentiating the Cochran-Armitage Trend Test and Pearson's χ

Zhengyang Zhou, Hung-Chih Ku, Zhipeng Huang, Guan Xing, Chao Xing

Abstract read
In one paragraph

Article in Annals of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Decomposing Pearson's χAnnals of human genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhengyang ZhouMcDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hung-Chih KuDepartment of Mathematical Sciences, DePaul University, Chicago, IL, USA.
Zhipeng HuangMcDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Guan XingGilead Sciences, Inc., Seattle, WA, USA.
Chao XingMcDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1838-0502

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
NCATS NIH HHS UL1 TR001105
6 · The paper itself

Abstract

In genetic case-control association studies, a standard practice is to perform the Cochran-Armitage (CA) trend test with 1 degree-of-freedom (d.f.) under the assumption of an additive model. However, when the true genetic model is recessive or near recessive, it is outperformed by Pearson's χ

Indexed as

Chi-Square DistributionModels, GeneticComputer SimulationDatabases, GeneticGenetic Association StudiesHumansdispersionlocationPearson's chi-squared testtrend test

Identifiers

PMID28653322
PMCPMC5552445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.