Evidence map›Paper›PMID 28653215›Full record

ArticleRheumatology international2017

NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.

Liuh Ling Goh, Mei Yun Yong, Wei Qiang See, Edward Yu Wing Chee, Pei Qi Lim, Ee Tzun Koh, Khai Pang Leong, TTSH RA Study Group

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Article in Rheumatology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liuh Ling GohTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. liuh_ling_goh@ttsh.com.sg.ORCID http://orcid.org/0000-0002-4877-537X
Mei Yun YongTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Wei Qiang SeeTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Edward Yu Wing CheeTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Pei Qi LimTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Ee Tzun KohDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore.
Khai Pang LeongTTSH Research Laboratory, Clinical Research and Innovation Office, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
TTSH RA Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have shown that the genetic risk factors for rheumatoid arthritis (RA) differ substantially between Asian and Caucasian populations. Even among Asian populations, the genetic contributions of NLRP1, PTPN22 and PADI4 have been controversial. Consequently, we sought to address these separate findings and determine whether any of these proposed risk variants are associated with RA susceptibility, onset, DAS activity and erosion in a Singaporean Chinese cohort. We genotyped five SNPs within NLRP1 (rs878329 and rs6502867), PTPN22 (rs2488457 and rs6665194), and PADI4 (rs2240340) in 500 anti-cyclic citrullinated peptide antibody-positive (ACPA) patients with RA and 500 healthy controls using TaqMan assays. The CC genotype of NLRP1 rs878329 and TT genotype of PADI4 rs2240340 were associated with RA susceptibility. The risk association of the T allele of PADI4 rs2240340 with RA was confirmed through a meta-analysis based on previous reports in Asian populations. The GG genotype of PTPN22 rs6665194 (-3508A>G) was associated with significantly reduced risk of RA. No significant association was found for NLRP1 rs6502867 T/C and PTPN22 rs2488457 G/C polymorphisms. None of the five SNPs was associated with RA's clinical features. This work supports the association of the T allele of PADI4 rs2240340 with RA in Asians. The roles of NLRP1 rs878329 G/C and PTPN22 rs6665194 A/G polymorphisms were demonstrated for the first time. We also propose rs6665194 to be a promising candidate for RA risk evaluation between ethnicities.

Indexed as

Genetic Predisposition to DiseaseAdaptor Proteins, Signal TransducingAdultAgedApoptosis Regulatory ProteinsArthritis, RheumatoidCase-Control StudiesChinaEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedNLR ProteinsPolymorphism, Single NucleotideProtein-Arginine DeiminasesAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsNLRP1 protein, humanNLR ProteinsPADI4 protein, humanProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 4Protein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanNLRP1PADI4PTPN22Rheumatoid arthritisSingle nucleotide polymorphism

Identifiers

PMID28653215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.