Evidence map›Paper›PMID 28653141›Full record

ReviewJournal of muscle research and cell motility2017

Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor.

Gaetano Santulli, Daniel R Lewis, Andrew R Marks

Open access · greenAbstract readReview
In one paragraph

Review in Journal of muscle research and cell motility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. Journal of neuromuscular diseases · 2026
    Article
  2. Article
  3. NMJ-associated transcriptomic remodeling correlates with disease severity in juvenile dermatomyositis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. MCU genetically altered mice suggest how mitochondrial CaTrends in endocrinology and metabolism: TEM · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. HAntioxidants (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Heart failure in diabetes.Metabolism: clinical and experimental · 2021
    Review
  18. Investigating gating mechanisms of ion channels using temperature-resolved cryoEM.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2021
    Article
  19. Review
  20. Fundamentals of Cellular Calcium Signaling: A Primer.Cold Spring Harbor perspectives in biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gaetano SantulliThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.ORCID 0000-0001-7231-375X
Daniel R LewisThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Andrew R MarksThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA. arm42@cumc.columbia.edu.
Columbia University Irving Medical Center · US

Funding

MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5M
Intracellular calcium leak and muscle functionR01AR060037 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2010 to 2014
$1.7M
Targeting intracellular calcium leak as novel therapy for diabetesK99DK107895 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTULLI, GAETANO · 2015 to 2016
$176k
NHLBI NIH HHS R01 HL061503NIAMS NIH HHS R01 AR060037NIDDK NIH HHS K99 DK107895
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

AnimalsCalciumExcitation Contraction CouplingHomeostasisHumansRyanodine Receptor Calcium Release ChannelCalciumRyanodine Receptor Calcium Release ChannelCalciumExcitation–contraction couplingMuscular dystrophyRyR1Skeletal muscle

Identifiers

PMID28653141
PMCPMC5813681
OpenAlexW2663964053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.