ArticleImmunogenetics2018
QPY/RAH haplotypes of the GZMB gene are associated with natural killer cell cytotoxicity.
Article in Immunogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
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- Screening of four lysosome-related genes in sepsis based on RNA sequencing technology.BMC immunology · 2023Article
- A common genetic variation inFrontiers in oncology · 2023Article
- Identification of molecular subtypes and immune infiltration in endometriosis: a novel bioinformatics analysis andFrontiers in immunology · 2023Article
- ATG16L1 is a Potential Prognostic Biomarker and Immune Signature for Osteosarcoma: A Study Based on Bulk RNA and Single-Cell RNA-Sequencing.International journal of general medicine · 2022Article
- Dietary supplementation ellagic acid on the growth, intestinal immune response, microbiota, and inflammation in weaned piglets.Frontiers in veterinary science · 2022Article
- Effects of a natural nutritional supplement on immune cell infiltration and immune gene expression in exercise-induced injury.Frontiers in nutrition · 2022Article
- Association of GZMB polymorphisms and susceptibility to non-segmental vitiligo in a Korean population.Scientific reports · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granzyme B (GzmB) is a component of cytolytic granules within NK cells and is involved in several pathologies. It has previously been reported that there are three non-synonymous coding SNPs (rs8192917; Q48R, rs11539752; P88A, and rs2236338; Y245H) in the GZMB gene and that the QPY/RAH allele was clustered together close to the C-terminal α-helix. However, it is unknown whether the function of GzmB produced from NK cells is influenced by QPY/RAH polymorphism. The authors investigated the distribution of QPY/RAH polymorphism of the GZMB gene in a Japanese population (n = 106), and the involvement of Q48R polymorphism in NK cell cytotoxicity, degranulation, and production of GzmB. A strong linkage disequilibrium was observed among these SNPs, and NK cell cytotoxicity was influenced by rs8192917 (Q48R). Moreover, it found that R
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