ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017
Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Parkinson disease is a fatty acidopathy.Nature reviews. Neurology · 2025Review
- The Role of Uridine in Health and Disease.Journal of inflammation research · 2025Review
- Accelerated cognitive aging in chronically infected HIV-1 positive individuals despite effective long-term antiretroviral therapy.Metabolic brain disease · 2024Article
- Nutrient Status and Intakes of Adults with Phenylketonuria.Nutrients · 2024Article
- Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels.Acta neuropathologica · 2023Article
- Fortasyn Connect Improves Neuropsychiatric Symptoms in Patients with Mild Cognitive Impairment and Dementia: Results from a Retrospective Real-World Study.Journal of Alzheimer's disease : JAD · 2023Article
- Article
- A metabolite panel that differentiates Alzheimer's disease from other dementia types.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review.Neurology and therapy · 2021Review
- Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation.Pharmaceuticals (Basel, Switzerland) · 2020Article
- LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Neuroprotective Effects of Choline and Other Methyl Donors.Nutrients · 2019Review
- Article
- Souvenaid in the management of mild cognitive impairment: an expert consensus opinion.Alzheimer's research & therapy · 2019Article
- Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.Fluids and barriers of the CNS · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSynaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's disease (AD). We assessed whether blood and cerebrospinal fluid (CSF) concentrations of nutrients related to phospholipid synthesis differ among patients with AD, mild cognitive impairment (MCI), and control subjects.
methodsConcentrations of uridine, choline, folate, homocysteine, and other related metabolites were analyzed in paired blood and CSF samples from subjects selected from the Amsterdam Dementia Cohort with AD (
resultsAge- and gender-adjusted analysis of variance revealed different concentrations of circulating uridine, choline, and folate and CSF uridine, folate, and homocysteine (all DISCUSSION: AD and MCI patients have lower levels of nutrients involved in phospholipid synthesis. The current observations warrant exploration of the application of nutritional strategies in the early stages of AD.
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Registered trials
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