Evidence map›Paper›PMID 28652926›Full record

ArticleBiomaterials research2017

Silk fibroin/hydroxyapatite composite hydrogel induced by gamma-ray irradiation for bone tissue engineering.

Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon, Won Ho Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min Hee KimDepartment of Advanced Organic Materials and Textile Engineering System, College of Engineering, Chungnam National University, Daejeon, 34134 South Korea.
Beom Su KimWonkwang Bone Regeneration Institute, Wonkwang University, Iksan, South Korea.
Jun LeeWonkwang Bone Regeneration Institute, Wonkwang University, Iksan, South Korea.
Donghwan ChoDepartment of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, South Korea.
Oh Hyeong KwonDepartment of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, South Korea.
Won Ho ParkDepartment of Advanced Organic Materials and Textile Engineering System, College of Engineering, Chungnam National University, Daejeon, 34134 South Korea.ORCID 0000-0003-1768-830X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the irradiation, the HAP dispersed SF solution was changed to the chemically crosslinked SF hydrogel.

methodsDistribution of HAP NPs in the SF hydrogel was examined by SEM imagery and energy dispersive X-ray spectrophotometry, and the crystalline structure of SF composite hydrogels was also confirmed by X-ray diffractometry. An optimum preparation condition of the SF/HAP composite hydrogels was determined with various HAP contents. For evaluation of the osteogenic differentiation of human mesenchymal stem cells (hMSCs), alkaline phosphatase activity (ALP), HAP nucleation in SBF and in vitro calcium accumulation were measured.

resultsThe results revealed that compared with the pure SF hydrogels, the SF/HAP composite hydrogels improved osteogenic differentiation.

conclusionThis paper demonstrates the great potential of the SF/HAP composite hydrogels in terms of the production of the bone tissue engineering scaffolds for which osteogenesis is required.

Indexed as

Bone tissue engineeringHydrogelHydroxyapatiteIrradiationSilk fibroin

Identifiers

PMID28652926
PMCPMC5483289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.