ArticleHepatic medicine : evidence and research2017
Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt.
Article in Hepatic medicine : evidence and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Transmission dynamics of human herpesvirus 6A, 6B and 7 from whole genome sequences of families.Virology journal · 2022Article
- Hepatitis C virus: A critical approach to who really needs treatment.World journal of hepatology · 2022Review
- Clustering of hepatitis C virus antibody positivity within households and communities in Punjab, India.Epidemiology and infection · 2019Article
- Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program.BMC infectious diseases · 2019Article
- Risk factors for familial clustering of hepatitis C virus infection in a Chinese Han population: a cross-sectional study.BMC public health · 2018Observational
- Prevalence of HCV Infection in Household Contacts of Chronic Liver Diseases Cases in Egypt.Journal of environmental and public health · 2018Article
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6 authors.
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Abstract
backgroundEgypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Although an effective HCV treatment program has been adopted, it is estimated that the number of newly reported cases in Egypt is still high. Intrafamilial transmission may play a role in the high prevalence of HCV in Egypt. Identification of risk factors for the transmission of HCV may help in decreasing its prevalence and eliminating its infection.
aimThe aim of this study was to estimate the prevalence of HCV infection among the household contacts of HCV patients and identify the possible risk factors associated with intrafamilial transmission.
methodsThis study was designed as a cohort study of 90 families of patients with confirmed chronic HCV and 38 families of non-HCV-infected persons. Diagnosis of HCV infection was performed by detection of HCV antibodies by fourth-generation enzyme-linked immunosorbent assay and confirmed by HCV RNA polymerase chain reaction. A pre-prepared questionnaire on risk factors was filled out by the participants. The prevalence of HCV was calculated, and univariate and multivariate analyses were carried out to identify the independent risk factors.
resultsAmong 90 positive-index families, 32 (35.6%) had contact persons with HCV infection compared to two of 38 (5.3%) negative-index families (
conclusionIntrafamilial transmission was found to possibly play a major role in the high prevalence of HCV in Egypt. Transmission was associated with older age and contact with patients with hepatic encephalopathy and was high among husbands of infected wives.
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