ArticleNeuropsychiatric disease and treatment2017
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The contributions of resting-state functional-MRI studies to our understanding of male patients with obstructive sleep apnea: a systematic review.Frontiers in neurology · 2025Pooled it
- The Reorganization of Cerebellar Functional Network Topology in Post-stroke Aphasia: A Resting-State fMRI Study.Molecular neurobiology · 2026Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Abnormal brain functional networks in systemic lupus erythematosus: a graph theory, network-based statistic and machine learning study.Brain communications · 2025Article
- Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea.CNS neuroscience & therapeutics · 2024Article
- Altered Functional Connectivity of Temporoparietal Lobe in Obstructive Sleep Apnea: A Resting-State fNIRS Study.Bioengineering (Basel, Switzerland) · 2024Article
- Decreased Memory-Related Regional Cerebral Perfusion in Severe Obstructive Sleep Apnea with a Mild Cognitive Impairment During Wakefulness.Nature and science of sleep · 2024Article
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- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Abnormal dynamic functional network connectivity in male obstructive sleep apnea with mild cognitive impairment: A data-driven functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2022Article
- Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder.Frontiers in aging neuroscience · 2022Article
- Widespread aberrant functional connectivity throughout the whole brain in obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study.Frontiers in neurology · 2021Article
- Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy.Frontiers in neurology · 2021Article
- Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study.Disease markers · 2021Article
- Alterations of neural network organization during REM sleep in women: implication for sex differences in vulnerability to mood disorders.Biology of sex differences · 2020Article
- Aberrant Awake Spontaneous Brain Activity in Obstructive Sleep Apnea: A Review Focused on Resting-State EEG and Resting-State fMRI.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObstructive sleep apnea (OSA) is a common sleep-related breathing disorder that can damage cognitive function. However, the functional network organization remains poorly understood. The aim of this study was to investigate the topological properties of OSA patients using a graph theoretical analysis. PATIENTS AND
methodsA total of 30 male patients with untreated severe OSA and 25 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (MRI) examinations. Clinical and cognitive evaluations were conducted by an experienced psychologist. GRETNA (a toolbox for topological analysis of imaging connectomics) was used to construct the brain functional network and calculate the small-world properties (γ, λ, σ, E
resultsThe networks of both OSA patients and GSs exhibited efficient small-world topology over the sparsity range of 0.05-0.40. Compared with GSs, the OSA group had significantly decreased γ, but significantly increased λ and σ. The OSA group's brain network showed significantly decreased E
conclusionOur results suggest that the high degree of local integration and integrity of the brain connections in OSA patients may be disrupted. The topological alterations of small-world properties may be the mechanism of cognitive impairment in OSA patients. In addition, σ, γ, and λ could be used as a quantitative physiological index for auxiliary clinical diagnoses.
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