ArticleInternational journal of nanomedicine2017
Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications.Journal of materials science. Materials in medicine · 2026Review
- Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts.Journal of biological engineering · 2025Article
- B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review.Frontiers in bioengineering and biotechnology · 2024Review
- IL-17A inhibits the degradation of RANKL in osteoblasts by inhibiting BCL2-Beclin1-autophagy signaling.In vitro cellular & developmental biology. Animal · 2023Article
- Article
- Roles of inflammatory cell infiltrate in periprosthetic osteolysis.Frontiers in immunology · 2023Review
- The dual role of autophagy in periprosthetic osteolysis.Frontiers in cell and developmental biology · 2023Review
- Beclin1- and Atg13-dependent autophagy activation and morroniside have synergistic effect on osteoblastogenesis.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling.Molecular biology reports · 2022Article
- Tantalum and magnesium nanoparticles enhance the biomimetic properties and osteo-angiogenic effects of PCL membranes.Frontiers in bioengineering and biotechnology · 2022Article
- Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review.Frontiers in bioengineering and biotechnology · 2022Review
- Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts.Aging · 2021Article
- Assessment of tantalum nanoparticle-induced MC3T3-E1 proliferation and underlying mechanisms.Journal of materials science. Materials in medicine · 2021Article
- PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation.Journal of bone and mineral metabolism · 2021Article
- Arbutin ameliorates glucocorticoid-induced osteoporosis through activating autophagy in osteoblasts.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2021Review
- Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration.Bioactive materials · 2021Article
- Tantalum Particles Induced Cytotoxic and Inflammatory Effects in Human Monocytes.BioMed research international · 2021Article
- Puerarin promotes the viability and differentiation of MC3T3-E1 cells by enhancing LC3B-mediated autophagy through downregulation of miR-204.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, and they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) that were deposited on the surface of a porous Ta implant are inevitably released and come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior and implant stabilization. However, the interaction of Ta-NPs with osteoblasts has not been clearly investigated. This study aimed to investigate the effect of Ta-NPs on cell proliferation and their underlying mechanism. The Cell Counting Kit-8 (CCK-8) assay was used to measure the cell viability of MC3T3-E1 mouse osteoblasts and showed that Ta-NP treatment could increase cell viability. Then, confocal microscopy, Western blotting, and transmission electron microscopy were used to confirm the autophagy induced by Ta-NPs, and evidence of autophagy induction was observed as positive LC3 puncta, high-LC3-II expression, and autophagic vesicle ultrastructures. The CCK-8 assay revealed that the cell viability was further increased and decreased by the application of an autophagy inducer and inhibitor, respectively. In addition, pre-treatment with autophagy inhibitor 3-methyladenine (3-MA) inhibited the Ta-NP-induced autophagy. These results indicate that the Ta-NPs can promote cell proliferation, that an autophagy inducer can further strengthen this effect and that an autophagy inhibitor can weaken this effect. In conclusion, autophagy was involved in Ta-NP-induced cell proliferation and had a promoting effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.