Evidence map›Paper›PMID 28652561›Full record

ReviewNeurologia medico-chirurgica2017

Chronic Subdural Hematoma in Elderly Patients: Is This Disease Benign?

Masaaki Uno, Hiroyuki Toi, Satoshi Hirai

Registry-linked trialOpen access · goldAbstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurologia medico-chirurgica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05713630 (TRACE STUDY), which is not on this map. Cited by 71 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05713630 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma

TypeinterventionalSponsorUnity Health TorontoRan2026 to 2030Enrolled130ConditionsSubdural HematomaArmsTranexamic acid (TXA), Placebo
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  9. Coil embolization alone appears sufficient for middle meningeal artery embolization.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Masaaki UnoDepartment of Neurosurgery, Kawasaki Medical School.
Hiroyuki ToiDepartment of Neurosurgery, Kawasaki Medical School.
Satoshi HiraiDepartment of Neurosurgery, Kawasaki Medical School.
Kawasaki Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the world population becomes progressively older, the overall incidence of chronic subdural hematoma (CSDH) is increasing. Peak age of onset for CSDH has also increased, and recently the 80-year-old level has a peak. Many patients with CSDH have had prior treatment with anticoagulants and antiplatelet drugs, which have an accompanying risk of CSDH. In elderly patients with CSDH, symptoms of cognitive change (memory disturbance, urinary incontinence, and decreased activity) and disturbance of consciousness at admission were more frequent compared to younger patients with CSDH. The literature actually offers conflicting advice regarding CSDH treatment; however, burr hole surgery with drainage under local anesthesia is the most common surgical procedure, even in elderly patients. The recurrence rate of CSDH has not decreased over recent decades, and it has ranged from 0.36-33.3%. Outcomes in patients over 75 years old was significantly worse than for those younger than 75. Moreover, long-term outcomes for elderly patients with CSDH are poor. CSDH in the elderly is no longer a benign disease. In the future, it will be important for us to understand the mechanisms of onset and recurrence of CSDH and to develop more effective medical treatments and noninvasive surgical techniques for elderly patients.

Indexed as

AgedAged, 80 and overAge of OnsetBrain Injuries, TraumaticCerebral HemorrhageCognition DisordersConsciousness DisordersCraniotomyDrainageFemaleHematologic AgentsHematoma, Subdural, ChronicHospital MortalityHumansJapanMaleHematologic Agentschronic subdural hematomaepidemiologylong-term outcomerecurrence ratetreatment

Identifiers

PMID28652561
PMCPMC5566699
OpenAlexW2717428026

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.