ArticleHypertension (Dallas, Tex. : 1979)2017
Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.
Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 107 citations in OpenAlex.
- Oral Losartan Treatment Improves Microvascular Endothelial Function via Nitric Oxide-Dependent Mechanisms in Women With a History of Preeclampsia.American journal of hypertension · 2025Trial
- Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy.Pregnancy hypertension · 2022Trial
- Local endothelin-1 receptor type A antagonism improves cutaneous microvascular function in women with a history of gestational diabetes mellitus.American journal of physiology. Heart and circulatory physiology · 2026Article
- Antecedent of Pregnancy-Related Cardiometabolic Complication and Risk of Cardiovascular Disease Among Women With Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Article
- Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2026Article
- The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026Review
- Methods for analyzing acetylcholine-induced vasodilation in human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026Article
- Cardiovascular disease in women: traditional and sex-specific risk factors.European heart journal · 2026Review
- Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Stress Trajectory and Hypertension 2 to 7 Years After Delivery: A nuMoM2b-HHS Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Renin-Angiotensin-Aldosterone System in Preeclampsia: Pathophysiological Insights and Links to Vascular Dementia.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Vascular endothelial function is preserved in women with a history of preeclampsia currently receiving antidepressant pharmacotherapy.American journal of physiology. Heart and circulatory physiology · 2026Article
- The multifactorial role of HDAC9 at the maternal-fetal interface in the pathogenesis of preeclampsia.Clinical science (London, England : 1979) · 2025Review
- The Impact of Preeclampsia and Gestational Diabetes on Future Maternal Cardiometabolic Health.Acta physiologica (Oxford, England) · 2025Review
- Higher Levels of Cardiovascular Biomarkers Following Hypertensive Compared to Normotensive Pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Association of physical activity, sedentary time, and sleep with maternal vascular function in women with a history of preeclampsia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Reductions in angiotensin II type 2 receptor-mediated vasodilation contribute to increased angiotensin II vasoconstrictor sensitivity in women with preeclampsia history.Clinical science (London, England : 1979) · 2025Article
- Reduced ATHypertension (Dallas, Tex. : 1979) · 2025Article
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia.Circulation research · 2025Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Women who have had preeclampsia have increased cardiovascular disease risk; however, the mechanism(s) responsible for this association remain unclear. Microvascular damage sustained during a preeclamptic pregnancy may persist postpartum. The putative mechanisms mediating this dysfunction include a reduction in NO-dependent dilation and an increased sensitivity to angiotensin II. In this study, we evaluated endothelium-dependent dilation, angiotensin II sensitivity, and the therapeutic effect of angiotensin II receptor blockade (losartan) on endothelium-dependent dilation in vivo in the microvasculature of women with a history of preeclampsia (n=12) and control women who had a healthy pregnancy (n=12). We hypothesized that preeclampsia would have (1) reduced endothelium-dependent dilation, (2) reduced NO-mediated dilation, and (3) increased sensitivity to angiotensin II. We further hypothesized that localized losartan would increase endothelium-dependent vasodilation in preeclampsia. We assessed microvascular endothelium-dependent vasodilator function by measurement of cutaneous vascular conductance responses to graded infusion of acetylcholine (acetylcholine; 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.