ArticleHypertension (Dallas, Tex. : 1979)2017
Systolic Blood Pressure and Biochemical Assessment of Adherence: A Cross-Sectional Analysis in the Emergency Department.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed.
- Feasibility and Short-Term Effects of a Multi-Component Emergency Department Blood Pressure Intervention: A Pilot Randomized Trial.Journal of the American Heart Association · 2022Trial
- Determinants of medication adherence in patients with diabetes, hypertension, and hyperlipidemia.Hormones (Athens, Greece) · 2025Article
- Comparison of Pharmacy Refill Data With Chemical Adherence Testing in Assessing Medication Nonadherence in a Safety Net Hospital Setting.Journal of the American Heart Association · 2022Article
- Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Antihypertensive medication adherence trends by sex and drug class: A pilot study.American heart journal plus : cardiology research and practice · 2021Article
- Is there any Hope for Monitoring Adherence in an Efficient and Feasible Way for Resistant Hypertension Diagnosis and Follow-Up?Current hypertension reports · 2020Review
- Improving Blood Pressure Among African Americans With Hypertension Using a Mobile Health Approach (the MI-BP App): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2019Article
- Direct assessment of adherence and drug interactions in patients with hypertensive crisis-A cross-sectional study in the Emergency Department.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Assessment of Patient Medication Adherence, Medical Record Accuracy, and Medication Blood Concentrations for Prescription and Over-the-Counter Medications.JAMA network open · 2018Article
- Hypertension: history and development of established and novel treatments.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Review
- Article
- Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation.Circulation research · 2018Review
- Advancing the Science and Practice of Medication Adherence.Journal of general internal medicine · 2018Review
- Medication adherence during laboratory workup for primary aldosteronism: pilot study.Patient preference and adherence · 2018Article
- Resistant hypertension-defining the scope of the problem.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
10 authors.
Candace D McNaughtonFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.). candace.mcnaughton@vanderbilt.edu.
Nancy J BrownFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Russell L RothmanFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Dandan LiuFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Edmond K KabagambeFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Phillip D LevyFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Wesley H SelfFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Alan B StorrowFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Sean P CollinsFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Christianne L RoumieFrom the Department of Emergency Medicine (C.D.M., W.H.S., A.B.S., S.P.C.), Department of Internal Medicine (N.J.B., R.L.R., C.L.R.), Department of Pediatrics (R.L.R., C.L.R.), Department of Biostatistics (D.L.), and Division of Epidemiology, Department of Medicine (E.K.K.), VUMC, Nashville, TN; Department of Emergency Medicine, Wayne State University, Detroit, MI (P.D.L.); and Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville (C.L.R.).
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MThe Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7MSalivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in AdultsK23GM110469 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SELF, WESLEY H · 2015 to 2018
$683kA Randomized, ED-based Intervention to Improve Antihypertensive AdherenceK23HL125670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCNAUGHTON, CANDACE · 2015 to 2017
$488kNCATS NIH HHS UL1 TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K23 HL125670NIGMS NIH HHS K23 GM110469
Abstract
Elevated blood pressure (BP) is common in the emergency department (ED), but the relationship between antihypertensive medication adherence and BP in the ED is unclear. This cross-sectional study tested the hypothesis that higher antihypertensive adherence is associated with lower systolic BP (SBP) in the ED among adults with hypertension who sought ED care at an academic hospital from July 2012 to April 2013. Biochemical assessment of antihypertensive adherence was performed using a mass spectrometry blood assay, and the primary outcome was average ED SBP. Analyses were stratified by number of prescribed antihypertensives (<3, ≥3) and adjusted for age, sex, race, insurance, literacy, numeracy, education, body mass index, and comorbidities. Among 85 patients prescribed ≥3 antihypertensives, mean SBP for adherent patients was 134.4 mm Hg (±26.1 mm Hg), and in adjusted analysis was -20.8 mm Hg (95% confidence interval, -34.2 to -7.4 mm Hg;
Indexed as
Antihypertensive AgentsHypertensionMass SpectrometryAgedBiomarkersBlood PressureBlood Pressure DeterminationCross-Sectional StudiesEmergency Medical ServicesEmergency Service, HospitalFemaleHealth LiteracyHumansMaleMedication AdherenceMedication Therapy ManagementAntihypertensive AgentsBiomarkersblood pressureemergency medical serviceshypertensionliteracymass spectrometrymedication adherence
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.