ArticleHypertension (Dallas, Tex. : 1979)2017
Blood Pressure, Antihypertensive Polypharmacy, Frailty, and Risk for Serious Fall Injuries Among Older Treated Adults With Hypertension.
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In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
8.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Effect of dual task-based training on motor and cognitive function in stroke patients: a systematic review and meta-analysis of randomized controlled trails.BMC neurology · 2025Pooled it
- Outcomes of hip fracture in centenarians: a systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Association between Frailty and Mortality, Falls, and Hospitalization among Patients with Hypertension: A Systematic Review and Meta-Analysis.BioMed research international · 2021Pooled it
- Effect of salt substitution on fracture-a secondary analysis of the Salt Substitute and Stroke Study (SSaSS).BMC medicine · 2024Trial
- L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.Frontiers in cardiovascular medicine · 2022Trial
- Association of Clinic Blood Pressure and Out-of-Clinic Blood Pressure Difference With Falls Among Older Adults With Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Efficacy and safety of antihypertensive drugs deprescribing in older adults: A systematic review and meta-analysis of randomized controlled trials.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- The effectiveness of motivational interviewing on self-management in older adults with hypertension and frailty: study protocol for a randomized controlled trial.Frontiers in public health · 2026Article
- Balance bridges upstream deficits associated with falls in older adults: evidence from the National Health and Aging Trends Study Round 13 cohort.Innovation in aging · 2026Article
- Relationship between serum PTH, potassium (K+), calcium (Ca2+), blood phosphate (PO4), parathyroid hormone (PTH), albumin (ALB) levels and orthostatic hypotension in hemodialysis patients.Journal of medical biochemistry · 2025Article
- Gender-Specific Patterns of Injury in Older Adults After a Fall from a Four-Wheeled Walker (Rollator): Retrospective Study from a Swiss Level 1 Trauma Centre.International journal of environmental research and public health · 2025Article
- Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD.Clinical interventions in aging · 2025Article
- Multimorbidity characteristics in older adults and their associated factors in complex networks: a cross-sectional study.Frontiers in public health · 2025Article
- Association of Questionnaire-Assessed Fall Risk With Uncontrolled Blood Pressure and Therapeutic Inertia Among Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Association of frailty status with overall survival in elderly hypertensive patients: based on the Chinese Longitudinal Healthy Longevity Survey.BMC public health · 2024Article
- Association between trajectories of systolic blood pressure and frailty outcome in middle-aged and older adults.The journal of nutrition, health & aging · 2024Article
- Prevalence of polypharmacy in the older adult population within primary care in Portugal: a nationwide cross-sectional study.Archives of medical science : AMS · 2024Article
- Review
- Brain activation in older adults with hypertension and normotension during standing balance task: an fNIRS study.Frontiers in aging neuroscience · 2024Article
- Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Samantha G BromfieldFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Cedric-Anthony NgameniFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Lisandro D ColantonioFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
C Barrett BowlingFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Daichi ShimboFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Kristi ReynoldsFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Monika M SaffordFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Maciej BanachFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Peter P TothFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.).
Paul MuntnerFrom the Department of Epidemiology, Emory University, Atlanta, GA (S.G.B.); Department of Epidemiology, University of Alabama at Birmingham, AL (L.D.C., P.M.); Cigna HealthSpring, Birmingham, AL (C.-A.N.); Department of Veterans Affairs, Geriatric Research, Education and Clinical Center, Durham, NC (C.B.B.); Department of Medicine, Columbia University Medical Center, New York, NY (D.S.); Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena (K.R.); Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.); Department of Hypertension, Medical University of Lodz, Poland (M.B.); Community General Hospital Medical Center, Sterling, IL (P.P.T.); and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.). pmuntner@uab.edu.
Cigna (United States) · USMedical University of Lodz · PLCGH Medical Center · USCornell University · USEmory University · USKaiser Permanente · USUniversity of Alabama at Birmingham · USWeill Cornell Medicine · US
Funding
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MREGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6MUnderstanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsR01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARY CUSHMAN, VIRGINIA J. HOWARD · 2001 to 2026
$8.8MIncorporation of a Hypertension Working Group into the Jackson Heart StudyR01HL117323 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E, OGEDEGBE, OLUGBENGA G. · 2013 to 2024
$7.2MMidcareer Investigator Award in Patient-Oriented Research in Human HypertensionK24HL125704 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHIMBO, DAICHI · 2015 to 2019
$573kBuilding Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556kNHLBI NIH HHS K24 HL111154NHLBI NIH HHS K24 HL125704NHLBI NIH HHS R01 HL080477NHLBI NIH HHS R01 HL117323NINDS NIH HHS R01 NS041588NINDS NIH HHS U01 NS041588
Abstract
Antihypertensive medication and low systolic blood pressure (BP) and diastolic BP have been associated with an increased falls risk in some studies. Many older adults have indicators of frailty, which may increase their risk for falls. We contrasted the association of systolic BP, diastolic BP, number of antihypertensive medication classes taken, and indicators of frailty with risk for serious fall injuries among 5236 REGARDS study (Reasons for Geographic and Racial Difference in Stroke) participants ≥65 years taking antihypertensive medication at baseline with Medicare fee-for-service coverage. Systolic BP and diastolic BP were measured, and antihypertensive medication classes being taken assessed through a pill bottle review during a study visit. Indicators of frailty included low body mass index, cognitive impairment, depressive symptoms, exhaustion, impaired mobility, and history of falls. Serious fall injuries were defined as fall-related fractures, brain injuries, or joint dislocations using Medicare claims through December 31, 2014. Over a median of 6.4 years, 802 (15.3%) participants had a serious fall injury. The multivariable-adjusted hazard ratio for a serious fall injury among participants with 1, 2, or ≥3 indicators of frailty versus no frailty indicators was 1.18 (95% confidence interval, 0.99-1.40), 1.49 (95% confidence interval, 1.19-1.87), and 2.04 (95% confidence interval, 1.56-2.67), respectively. Systolic BP, diastolic BP, and number of antihypertensive medication classes being taken at baseline were not associated with risk for serious fall injuries after multivariable adjustment. In conclusion, indicators of frailty, but not BP or number of antihypertensive medication classes, were associated with increased risk for serious fall injuries among older adults taking antihypertensive medication.
Indexed as
Antihypertensive AgentsDrug-Related Side Effects and Adverse ReactionsHypertensionWounds and InjuriesAccidental FallsAgedBlood PressureBlood Pressure DeterminationFemaleFollow-Up StudiesFrail ElderlyHumansMaleMedicarePolypharmacyRisk AdjustmentAntihypertensive Agentsagedblood pressurehypertensionpolypharmacy
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