ArticleIn vivo (Athens, Greece)
Hepatic Epithelioid Hemangioendothelioma - a Rare Tumor and Diagnostic Dilemma.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Characteristics of patients with epithelioid hemangioendothelioma (EHE): a retrospective analysis of the Charité- Universitätsmedizin Berlin.Journal of cancer research and clinical oncology · 2026Article
- Pulsed ultrasound-stimulated microbubbles alter the tumor blood supply to enhance the efficacy of high-intensity focused ultrasound ablation of vascular tumors.Frontiers in oncology · 2026Article
- Article
- CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases.Frontiers in oncology · 2025Article
- Irreversible Electroporation as a Valid Treatment Option for Hepatic Epithelioid Hemangioendothelioma: An International Multicenter Experience.Cardiovascular and interventional radiology · 2024Article
- Three cases of hepatic epithelioid hemangioendothelioma evaluated using conventional and contrast-enhanced ultrasound: Case reports.Journal of clinical ultrasound : JCU · 2022Article
- Hepatic epithelioid hemangioendothelioma after thirteen years' follow-up: A case report and review of literature.World journal of clinical cases · 2022Article
- Hepatic epithelioid hemangioendothelioma simulating liver metastasis: A case report.Annals of medicine and surgery (2012) · 2021Article
- Metastatic Hepatic Epitheloid Hemangioendothelioma in a Young Male: A Rare Presentation.Gastrointestinal tumors · 2021Article
- Triple whammy: a rare case of epithelioid hemangioendothelioma with synchronous angiomyomatous hamartoma complicated byArchive of clinical cases · 2021Article
- Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy.World journal of clinical cases · 2020Review
- Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases.Diagnostic pathology · 2020Article
- Surgical treatment of asymptomatic epithelioid hemangioendothelioma originating from the superior vena cava: A case report.Medicine · 2020Article
- Hepatic epitheloid haemangioendothelioma: a rare malignant tumour.BMJ case reports · 2020Article
- Hepatic epithelioid hemangioendothelioma associated with acute disseminated encephalomyelitis by a possible paraneoplastic process.Rare tumors · 2020Article
- Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?Therapeutics and clinical risk management · 2020Article
- Selection of treatment for hepatic epithelioid hemangioendothelioma: a single-center experience.World journal of surgical oncology · 2019Article
- Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management.World journal of clinical oncology · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimHepatic epithelioid haemangio-endothelioma (HEHE) is a very rare malignant tumor of vascular origin and uncertain biological behaviour that is difficult to diagnose using preoperative radiology diagnostic techniques. PATIENTS AND
methodsThe authors present here two patients with HEHE of different extent. The first patient had a generalised form of disease, with involvement of the liver, lungs and bones and was treated with a combination of bevacizumab and capecitabine. The second patient had a localised form of disease involving the liver and this was resolved using a combination of liver resection and radiofrequency ablation. In both patients, the radiology work-up before surgery was non-specific and metastases of another malignant process were considered. The definitive histological diagnosis was made by the pathologist on the basis of immunohistochemical analysis that demonstrated the presence of CD31, CD34 and calmodulin-binding transcription activator 1 (CAMTA 1).
resultsBoth patients remain in an overall good condition 27 and 5 months respectively following treatment for HEHE.
conclusionPreoperative radiological diagnosis of HEHE is difficult and immunohistochemical examination of the tumor tissue sample remains the key diagnostic tool. Radical surgical resection or liver transplantation is the method of choice in patients with localised liver involvement.
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