ArticleIn vivo (Athens, Greece)
Elevated IL-4 and IFN-γ Levels in Muscle Tissue of Patients with Dermatomyositis.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03529955 (A Phase 2, Open Label Single Arm Study for Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2, Open Label Single Arm Study for Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation.Science translational medicine · 2025Article
- Apremilast treatment of immune-mediated inflammatory skin diseases: a narrative review.Frontiers in pharmacology · 2025Review
- Major histocompatibility complex I-induced endoplasmic reticulum stress mediates the secretion of pro-inflammatory muscle-derived cytokines.Journal of cellular and molecular medicine · 2022Article
- Past, Present, and Future in Dermatomyositis Therapeutics.Current treatment options in rheumatology · 2022Article
- Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects.International journal of molecular sciences · 2022Article
- A novel model of dermatomyositis induced by membrane antigen and calciphylaxis in rats.Biomedical reports · 2022Article
- Highly Multiplexed Mass Cytometry Identifies the Immunophenotype in the Skin of Dermatomyositis.The Journal of investigative dermatology · 2021Article
- Serum levels of interleukins and S100A8/A9 correlate with clinical severity in patients with dermatomyositis-associated interstitial lung disease.BMC pulmonary medicine · 2020Article
- A high level of serum neopterin is associated with rapidly progressive interstitial lung disease and reduced survival in dermatomyositis.Clinical and experimental immunology · 2020Article
- Apremilast as a potential treatment for moderate to severe dermatomyositis: A retrospective study of 3 patients.JAAD case reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimTo investigate the contribution of muscle tissue-derived cytokines in dermatomyositis (DM). MATERIALS AND
methodsMuscle homogenates were prepared from deltoid muscle biopsy specimens of 10 patients with DM and eight controls with no pathological signs of myopathy. Interleukin (IL)-4, interferon (IFN)-γ and IL-17 levels were evaluated by enzyme-linked immunosorbent assay (ELISA) and immunoblotting analysis. Muscle strength grades were recorded.
resultsPatients with DM showed significantly elevated muscle tissue IL-4 and IFN-γ levels, whereas IL-17 levels were comparable between patients with DM and controls. Immunoblotting studies confirmed ELISA results. In DM muscle specimens, IL-4 and IFN-γ levels were positively correlated, while no correlation was observed between IL-17 and the other two cytokines. Moreover, IL-4 and IFN-γ levels were significantly negative correlated with muscle strength grades for the deltoid muscle.
conclusionOur results confirm the involvement of T helper (Th) 1-type and Th2-type immunity in DM pathogenesis. Muscle tissue appears to contribute to muscle weakness in DM by producing inflammatory cytokines.
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