Evidence map›Paper›PMID 28652430›Full record

ArticleIn vivo (Athens, Greece)

The Contribution of

Cheng-Hsi Liao, Wen-Shin Chang, Pei-Shin Hu, Hsi-Chin Wu, Shih-Wei Hsu, Yen-Fang Liu, Shih-Ping Liu, Huey-Shan Hung, DA-Tian Bau, Chia-Wen Tsai

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Association ofIn vivo (Athens, Greece)
    Article
  5. Article
  6. The Association ofIn vivo (Athens, Greece)
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Contribution ofCancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Cheng-Hsi LiaoGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Wen-Shin ChangTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Pei-Shin HuDepartment of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
Hsi-Chin WuTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Shih-Wei HsuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Yen-Fang LiuTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Shih-Ping LiuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Huey-Shan HungGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
DA-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.
Chia-Wen TsaiTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMounting evidence has suggested that polymorphisms in the promoters of matrix metalloproteinase (MMP) genes are associated with the risk of many types of cancer, but no study has ever explored these polymorphisms as biomarkers for renal cell cancer (RCC). Recently, it was suggested that serum MMP-7 levels have both diagnostic and prognostic potential for RCC. In this study, we focused on the contribution of two functional polymorphisms in the promoter region of MMP-7 (A-181G and C-153T) to RCC. MATERIALS AND

methodsThese two polymorphisms were genotyped in 92 patients with RCC and 580 controls by PRC-RFLP analysis.

resultsThe results showed that there is no significant association of the RCC risk with the MMP-7 A-181G genotype, even after adjusted for the possible confounding factors. The MMP-7 C-153T polymorphism was not identified among the subjects investigated.

conclusionOur findings suggest that the two MMP-7 polymorphisms A-181G and C-153T do not play a major role in determining personal susceptibility to RCC in Taiwan.

Indexed as

Genetic Predisposition to DiseaseAdultAgedAllelesBiomarkers, TumorCarcinoma, Renal CellFemaleGenetic Association StudiesGenotypeHumansMaleMatrix Metalloproteinase 7Middle AgedPolymorphism, Single NucleotidePrognosisPromoter Regions, GeneticBiomarkers, TumorMatrix Metalloproteinase 7GenotypeMMP-7polymorphismrenal cell cancerTaiwan

Identifiers

PMID28652430
PMCPMC5566913
OpenAlexW2643770656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.