ArticleJournal of immunology (Baltimore, Md. : 1950)2017
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- TLR7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity.Science advances · 2026Article
- singIST: An integrative method for comparative single-cell transcriptomics between disease models and humans.PLoS computational biology · 2026Article
- Mechanisms governing bystander activation of T cells.Frontiers in immunology · 2024Review
- Regulating Th17/Treg Balance Contributes to the Therapeutic Effect of Ziyuglycoside I on Collagen-Induced Arthritis.International journal of molecular sciences · 2022Article
- Combination of STING and TLR 7/8 Agonists as Vaccine Adjuvants for Cancer Immunotherapy.Cancers · 2022Article
- The role of Th17 cells in inflammatory bowel disease and the research progress.Frontiers in immunology · 2022Review
- Sequence-specific extracellular microRNAs activate TLR7 and induce cytokine secretion and leukocyte migration.Molecular and cellular biochemistry · 2021Article
- IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion.Cellular & molecular immunology · 2021Article
- Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?NPJ vaccines · 2021Review
- Toll-like Receptor 2 in Autoimmune Inflammation.Immune network · 2021Review
- Resolvin E1 Regulates Th17 Function and T Cell Activation.Frontiers in immunology · 2021Article
- Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis.Frontiers in immunology · 2021Article
- Identification of the Association Between Toll-Like Receptors and T-Cell Activation in Takayasu's Arteritis.Frontiers in immunology · 2021Article
- NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.The Journal of experimental medicine · 2020Article
- Innate Immune Sensing by Cells of the Adaptive Immune System.Frontiers in immunology · 2020Review
- Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep.Scientific reports · 2019Article
- Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization.iScience · 2019Article
- Bystander T Cells: A Balancing Act of Friends and Foes.Trends in immunology · 2018Review
- Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy.Cellular & molecular immunology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Innate regulation through TLR signaling has been shown to be important for promoting T cell subset development and function. However, limited information is known about whether differential TLR signaling can selectively inhibit Th17 and/or Th1 cells, which are important for controlling excessive inflammation and autoimmune responses. In this article, we demonstrate that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells. We further report that downregulation of STAT3 signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5. TLR7-mediated suppression of Th17 cells does not require dendritic cell involvement. In addition, we show that TLR7 signaling can suppress Th1 cell development and function through a mechanism different from Th17 cell suppression. Importantly, our complementary in vivo studies demonstrate that treatment with the TLR7 ligand imiquimod can inhibit Th1 and Th17 cells, resulting in the prevention of, and an immunotherapeutic reduction in, experimental autoimmune encephalomyelitis. These studies identify a new strategy to manipulate Th17/Th1 cells through TLR7 signaling, with important implications for successful immunotherapy against autoimmune and inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.