Evidence map›Paper›PMID 28652347›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts.

Jaira F de Vasconcellos, Laxminath Tumburu, Colleen Byrnes, Y Terry Lee, Pauline C Xu, May Li, Antoinette Rabel, Benjamin A Clarke, Nicholas R Guydosh, Richard L Proia and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Dissecting polycomb complexes for enhanced fetal hemoglobin production.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Regulation of HSC development and function by Lin28b.Frontiers in cell and developmental biology · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Transcriptional Repressor BCL11A in Erythroid Cells.Advances in experimental medicine and biology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jaira F de VasconcellosGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Laxminath TumburuMolecular Medicine Branch, NIDDK, NIH, Bethesda, MD 20892.
Colleen ByrnesGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Y Terry LeeGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Pauline C XuGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
May LiGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Antoinette RabelGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Benjamin A ClarkeGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Nicholas R GuydoshLaboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892.
Richard L ProiaGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892.
Jeffery L MillerGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892; jm7f@nih.gov.
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · USDana-Farber Cancer Institute · US

Funding

Molecular mechanism of the ribosome and functions of translational regulationZIADK075132 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GUYDOSH, NICHOLAS · 2016 to 2025
$14.3M
Regulation of Fetal Hemoglobin Production in Humans.ZIADK025101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MILLER, JEFFERY · 2009 to 2016
$3.4M
6 · The paper itself

Abstract

Here we investigated in primary human erythroid tissues a downstream element of the heterochronic

Indexed as

Gene Expression ProfilingGene Expression Regulationbeta-GlobinsBone MarrowCarrier ProteinsErythroblastsFetal Hemoglobingamma-GlobinsHEK293 CellsHMGA2 ProteinHumansInsulin-Like Growth Factor Binding Protein 3LiverNuclear ProteinsPhenotypeRepressor ProteinsBCL11A protein, humanbeta-GlobinsCarrier ProteinsFetal Hemoglobingamma-GlobinsHMGA2 ProteinIGF2BP1 protein, humanIGF2BP2 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Nuclear ProteinsRepressor ProteinsRNA-Binding ProteinsRNA, Messengerfetal hemoglobinIGF2BP1IMP1let-7 targetsontogeny

Identifiers

PMID28652347
PMCPMC5514697
OpenAlexW2632422275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.