Evidence map›Paper›PMID 28652344›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.

Katsuhiko S Murakami, Yeonoh Shin, Charles L Turnbough, Vadim Molodtsov

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Structural and mechanistic basis of reiterative transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katsuhiko S MurakamiDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802; kum14@psu.edu vum5@psu.edu.
Yeonoh ShinDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802.
Charles L TurnboughDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170.
Vadim MolodtsovDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802; kum14@psu.edu vum5@psu.edu.

Funding

X-Ray Crystallographic Studies of Multi-Subunit Nucleic Acid PolymerasesR01GM087350 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MURAKAMI, KATSUHIKO · 2010 to 2018
$2.6M
Bacterial gene regulation by the NTP substrates of transcription initiationR01GM094466 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TURNBOUGH, CHARLES LEE · 2010 to 2013
$1.1M
NIGMS NIH HHS R01 GM087350NIGMS NIH HHS R01 GM094466
6 · The paper itself

Abstract

Reiterative transcription is a noncanonical form of RNA synthesis in which a nucleotide specified by a single base in the DNA template is repetitively added to the nascent transcript. Here we determined the crystal structure of an RNA polymerase, the bacterial enzyme from

Indexed as

Transcription, GeneticBacillus subtilisBacterial ProteinsCrystallography, X-RayDNA-Directed RNA PolymerasesEscherichia coliModels, MolecularMutationPoly GPromoter Regions, GeneticRifampinRNA, BacterialThermus thermophilusBacterial ProteinsDNA-Directed RNA PolymerasesPoly GRifampinRNA, Bacterialreiterative transcriptionRNA polymerasetranscription initiationtranscript slippageX-ray crystal structure

Identifiers

PMID28652344
PMCPMC5547606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.