Evidence map›Paper›PMID 28652309›Full record

ArticleInfection and immunity2017

Host and Pathogen Copper-Transporting P-Type ATPases Function Antagonistically during Salmonella Infection.

Erik Ladomersky, Aslam Khan, Vinit Shanbhag, Jennifer S Cavet, Jefferson Chan, Gary A Weisman, Michael J Petris

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 60 citations in OpenAlex.

  1. A copper uptake ABC transport system is essential forEmerging microbes & infections · 2026
    Article
  2. Review
  3. A broad-spectrum inhibitor of copper-exporting PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. A First-In-Class Broad Spectrum Inhibitor of Copper Exporting PbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Identification and Analysis of Fungal-Specific Regions in theInternational journal of molecular sciences · 2023
    Article
  13. Review
  14. Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023
    Review
  15. Review
  16. Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  17. Evolution of Copper Homeostasis and Virulence inFrontiers in microbiology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Erik LadomerskyDepartment of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Aslam KhanDepartment of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Vinit ShanbhagDepartment of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Jennifer S CavetFaculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom.
Jefferson ChanDepartments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California, USA.
Gary A WeismanDepartment of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Michael J PetrisDepartment of Biochemistry, University of Missouri, Columbia, Missouri, USA petrism@missouri.edu.
University of Missouri · USManchester Academic Health Science Centre · GBUniversity of California, Berkeley · US

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Tissue-specific pathways of copper homeostasis in growth and developmentR01DK093386 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2011 to 2016
$2.3M
Biotechnology and Biological Sciences Research Council BB/G010765/1NIDDK NIH HHS R01 DK093386NIGMS NIH HHS R01 GM079465
6 · The paper itself

Abstract

Copper is an essential yet potentially toxic trace element that is required by all aerobic organisms. A key regulator of copper homeostasis in mammalian cells is the copper-transporting P-type ATPase ATP7A, which mediates copper transport from the cytoplasm into the secretory pathway, as well as copper export across the plasma membrane. Previous studies have shown that ATP7A-dependent copper transport is required for killing phagocytosed

Indexed as

Host-Pathogen InteractionsAdenosine TriphosphatasesAnimalsCation Transport ProteinsCopperFemaleMacrophagesMaleMice, KnockoutSalmonella Infections, AnimalSalmonella typhimuriumVirulenceAdenosine TriphosphatasesCation Transport ProteinsCopperATP7A copper transporterbacterial copper tolerancebacterial infectioncopper toxicityhost-pathogen interactionsimmunology and infectionmacrophagesnutritional immunitySalmonella Typhimurium

Identifiers

PMID28652309
PMCPMC5563570
OpenAlexW2715686896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.