Evidence map›Paper›PMID 28652308›Full record

ArticleInfection and immunity2017

B10 Cells Alleviate Periodontal Bone Loss in Experimental Periodontitis.

Yuhua Wang, Xiaoqian Yu, Jiang Lin, Yang Hu, Qian Zhao, Toshihisa Kawai, Martin A Taubman, Xiaozhe Han

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yuhua WangThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Xiaoqian YuThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Jiang LinThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Yang HuThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Qian ZhaoThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Toshihisa KawaiThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Martin A TaubmanThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Xiaozhe HanThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA Xhan@forsyth.org.
Capital Medical University · CNHarbin Medical University · CNPeking University · CNShanghai Jiao Tong University · CN

Funding

Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal DiseaseR01DE025255 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2015 to 2025
$5.8M
Regulatory B cells in the amelioration of immune-mediated periodontal diseaseR56DE023807 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HAN, XIAOZHE · 2014 to 2014
$476k
NIDCR NIH HHS R01 DE025255NIDCR NIH HHS R56 DE023807
6 · The paper itself

Abstract

B10 cells can regulate inflammatory responses in innate immunity. Toll-like receptors (TLRs) play an important role in B cell-mediated immune responses in periodontal disease. This study aimed to determine the effects of TLR-activated B10 cells on periodontal bone loss in experimental periodontitis. Spleen B cells isolated from C57BL/6J mice were cultured with

Indexed as

Adoptive TransferAlveolar Bone LossAnimalsB-LymphocytesCell- and Tissue-Based TherapyDisease Models, AnimalMaleMice, Inbred C57BLPeriodontitisPorphyromonas gingivalisTreatment OutcomeB cellCpGlipopolysaccharideLPSperiodontitisToll-like receptor

Identifiers

PMID28652308
PMCPMC5563573
OpenAlexW2687183192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.