Evidence map›Paper›PMID 28652306›Full record

ArticleInfection and immunity2017

Hepcidin-(In)dependent Mechanisms of Iron Metabolism Regulation during Infection by Listeria and Salmonella.

Ana C Moreira, João V Neves, Tânia Silva, Patrícia Oliveira, Maria S Gomes, Pedro N Rodrigues

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Innate Nutritional Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ana C Moreirai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
João V Nevesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Tânia Silvai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Patrícia Oliveirai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Maria S Gomesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal sgomes@ibmc.up.pt.ORCID http://orcid.org/0000-0001-7657-2118
Pedro N Rodriguesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During bacterial infection, the pathogenic agent and the host battle for iron, due to its importance for fundamental cellular processes. However, iron redistribution and sequestration during infection can culminate in anemia. Although hepcidin has been recognized as the key regulator of iron metabolism, in some infections its levels remain unaffected, suggesting the involvement of other players in iron metabolism deregulation. In this work, we use a mouse model to elucidate the main cellular and molecular mechanisms that lead to iron redistribution during infection with two different pathogens:

Indexed as

AnimalsDisease Models, AnimalGene Expression ProfilingHepcidinsIronListeriosisMaleMice, Inbred C57BLMice, KnockoutSalmonella InfectionsHepcidinsIronhost-pathogen interactionsinfectioninnate immunityiron metabolismListeria monocytogenesSalmonella Typhimurium

Identifiers

PMID28652306
PMCPMC5563588
OpenAlexW2719144121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.