Evidence map›Paper›PMID 28652301›Full record

ArticleJournal of bacteriology2017

Stand-Alone EAL Domain Proteins Form a Distinct Subclass of EAL Proteins Involved in Regulation of Cell Motility and Biofilm Formation in Enterobacteria.

Youssef El Mouali, Hyunhee Kim, Irfan Ahmad, Annelie Brauner, Ying Liu, Mikael Skurnik, Michael Y Galperin, Ute Römling

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  3. ComFB, a widespread family of c-di-NMP receptor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  5. ComFB, a new widespread family of c-di-NMP receptor proteins.bioRxiv : the preprint server for biology · 2024
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  6. Functional analysis of cyclic diguanylate-modulating proteins inbioRxiv : the preprint server for biology · 2024
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  8. Review
  9. Comparative genomics ofFrontiers in microbiology · 2023
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  10. Anti-bacterial and Anti-biofilm Effects of Equol onIndian journal of microbiology · 2022
    Article
  11. Article
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  14. Review
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  20. Features of formation ofVeterinary world · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Youssef El MoualiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Hyunhee KimDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Irfan AhmadDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Annelie BraunerDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Ying LiuDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Mikael SkurnikDepartment of Bacteriology and Immunology, Medicum, Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-8791-9260
Michael Y GalperinNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA galperin@ncbi.nlm.nih.gov Ute.Romling@ki.se.ORCID http://orcid.org/0000-0002-2265-5572
Ute RömlingDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden galperin@ncbi.nlm.nih.gov Ute.Romling@ki.se.ORCID http://orcid.org/0000-0003-3812-6621
Karolinska Institutet · SENational Institutes of Health · USUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The second messenger cyclic dimeric GMP (c-di-GMP) is almost ubiquitous among bacteria as are the c-di-GMP turnover proteins, which mediate the transition between motility and sessility. EAL domain proteins have been characterized as c-di-GMP-specific phosphodiesterases. While most EAL domain proteins contain additional, usually N-terminal, domains, there is a distinct family of proteins with stand-alone EAL domains, exemplified by

Indexed as

Gene Expression Regulation, BacterialLocomotionBacterial ProteinsBiofilmsCluster AnalysisComputational BiologyConserved SequenceCyclic GMPEnterobacteriaceaePhosphoric Diester HydrolasesPhylogenySequence Homology, Amino AcidBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPPhosphoric Diester Hydrolasescyclic di-GMP phosphodiesteraseflagellar regulonFlhDCmotilityprotein-protein interaction

Identifiers

PMID28652301
PMCPMC5573086
OpenAlexW2683713387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.