Evidence map›Paper›PMID 28652239›Full record

ArticleAntimicrobial agents and chemotherapy2017

Targeting the Homoserine Dehydrogenase of Paracoccidioides Species for Treatment of Systemic Fungal Infections.

Mariane C Bagatin, Arethusa L Pimentel, Débora C Biavatti, Ernani A Basso, Erika S Kioshima, Flavio A V Seixas, Gisele de F Gauze

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Proteomic Response ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  6. One Century of Study: What We Learned aboutJournal of fungi (Basel, Switzerland) · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariane C BagatinDepartment of Chemistry, State University of Maringá, Maringá, PR, Brazil.
Arethusa L PimentelDepartment of Biochemistry, State University of Maringá, Maringá, PR, Brazil.
Débora C BiavattiDepartment of Biochemistry, State University of Maringá, Maringá, PR, Brazil.
Ernani A BassoDepartment of Chemistry, State University of Maringá, Maringá, PR, Brazil.
Erika S KioshimaDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.
Flavio A V SeixasDepartment of Biochemistry, State University of Maringá, Maringá, PR, Brazil.
Gisele de F GauzeDepartment of Chemistry, State University of Maringá, Maringá, PR, Brazil giselegauze@yahoo.com.br.
Universidade Estadual de Maringá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work evaluated new potential inhibitors of the enzyme homoserine dehydrogenase (HSD) of

Indexed as

Antifungal AgentsCell Line, TumorHeLa CellsHomoserine DehydrogenaseHumansItraconazoleMicrobial Sensitivity TestsParacoccidioidesParacoccidioidomycosisAntifungal AgentsHomoserine DehydrogenaseItraconazoleantifungalhomoserine dehydrogenaseparacoccidioidomycosisvirtual screening

Identifiers

PMID28652239
PMCPMC5571355
OpenAlexW2711578309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.