Trial reportAcademic radiology2017
The Efficacy of Low-intensity Vibration to Improve Bone Health in Patients with End-stage Renal Disease Is Highly Dependent on Compliance and Muscle Response.
Trial report in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Low-Intensity Vibration to Reduce Symptoms and Improve Physical Functioning in Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Pilot Randomized Trial.JCO oncology practice · 2026Trial
- Changes in bone microarchitecture following parathyroidectomy in patients with secondary hyperparathyroidism.Bone reports · 2021Article
- Bone microarchitecture in patients undergoing parathyroidectomy for management of secondary hyperparathyroidism.Bone reports · 2020Article
- High Levels of Physical Activity May Promote a Reduction in Bone Mineral Density in Peritoneal Dialysis.Medicina (Kaunas, Lithuania) · 2020Article
- The long-term residual effects of low-magnitude mechanical stimulation therapy on skeletal health.Journal of biological engineering · 2020Article
- Micro-Finite Element Analysis of the Proximal Femur on the Basis of High-Resolution Magnetic Resonance Images.Current osteoporosis reports · 2018Review
- Whole body vibration to attenuate reduction of explosive force in chronic kidney disease patients: a randomized controlled trial.Journal of exercise rehabilitation · 2018Article
- Trinity of Three-Dimensional (3D) Scaffold, Vibration, and 3D Printing on Cell Culture Application: A Systematic Review and Indicating Future Direction.Bioengineering (Basel, Switzerland) · 2018Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
RATIONAL AND
objectivesLow intensity vibration (LIV) may represent a nondrug strategy to mitigate bone deficits in patients with end-stage renal disease. MATERIALS AND
methodsThirty end-stage renal patients on maintenance hemodialysis were randomized to stand for 20 minutes each day on either an active or placebo LIV device. Analysis at baseline and completion of 6-month intervention included magnetic resonance imaging (tibia and fibula stiffness; trabecular thickness, number, separation, bone volume fraction, plate-to-rod ratio; and cortical bone porosity), dual-energy X-ray absorptiometry (hip and spine bone mineral density [BMD]), and peripheral quantitative computed tomography (tibia trabecular and cortical BMD; calf muscle cross-sectional area).
resultsIntention-to-treat analysis did not show any significant changes in outcomes associated with LIV. Subjects using the active device and with greater than the median adherence (70%) demonstrated an increase in distal tibia stiffness (5.3%), trabecular number (1.7%), BMD (2.3%), and plate-to-rod ratio (6.5%), and a decrease in trabecular separation (-1.8%). Changes in calf muscle cross-sectional area were associated with changes in distal tibia stiffness (R = 0.85), trabecular bone volume/total volume (R = 0.91), number (R = 0.92), and separation (R = -0.94) in the active group but not in the placebo group. Baseline parathyroid hormone levels were positively associated with increased cortical bone porosity over the 6-month study period in the placebo group (R = 0.55) but not in the active group (R = 0.01). No changes were observed in the nondistal tibia locations for either group except a decrease in hip BMD in the placebo group (-1.7%).
conclusionOutcomes and adherence thresholds identified from this pilot study could guide future longitudinal studies involving vibration therapy.
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