Evidence map›Paper›PMID 28651822›Full record

ArticleJournal of voice : official journal of the Voice Foundation2018

Pharyngeal Dystonia Mimicking Spasmodic Dysphonia.

Lucy L Shi, C Blake Simpson, Edie R Hapner, Hyder A Jinnah, Michael M Johns

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In one paragraph

Article in Journal of voice : official journal of the Voice Foundation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucy L ShiEmory University School of Medicine, Atlanta, Georgia.
C Blake SimpsonDepartment of Otolaryngology-Head & Neck Surgery, University of Texas Health Science Center, San Antonio, Texas.
Edie R HapnerEmory Voice Center, Department of Otolaryngology-Head & Neck Surgery, Emory University School of Medicine, Atlanta, Georgia.
Hyder A JinnahDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia.
Michael M JohnsEmory Voice Center, Department of Otolaryngology-Head & Neck Surgery, Emory University School of Medicine, Atlanta, Georgia. Electronic address: johnsmd@me.com.

Funding

Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
NCATS NIH HHS U54 TR001456NINDS NIH HHS U54 NS065701
6 · The paper itself

Abstract

objectiveThe aim of this study was to describe the presentation of pharyngeal dystonia (PD), which can occur as a focal or segmental dystonia with a primarily pharyngeal involvement for the discussion of treatment methods for controlling consequent symptoms. PD is specific to speech-related tasks.

methodsA retrospective medical record review of four patients with PD was performed.

resultsAll patients were initially misdiagnosed with adductor spasmodic dysphonia and failed standard treatment with botulinum toxin type A (BTX). On laryngoscopy, the patients were discovered to have segmental or focal dystonia primarily affecting the pharyngeal musculature contributing to their vocal manifestations. A novel treatment regimen was designed, which involved directing BTX injections into the muscles involved in spasmodic valving at the oropharyngeal level. After titrating to an optimal dose, all patients showed improvement in their voice and speech with only mild dysphagia. These patients have maintained favorable results with repeat injections at 6- to 12-week intervals.

conclusionsPD, or dystonia with predominant pharyngeal involvement, is a rare entity with vocal manifestations that are not well described. It can be easily mistaken for spasmodic dysphonia. PD is specific to speech-related tasks. A novel method of BTX injections into the involved muscles results in a significant improvement in voice without significant dysphagia.

Indexed as

LaryngoscopySpeech AcousticsVoice QualityAcetylcholine Release InhibitorsAgedBotulinum Toxins, Type ADiagnosis, DifferentialDiagnostic ErrorsDysphoniaFemaleHumansInjections, IntramuscularMaleMedical RecordsMiddle AgedPharyngeal DiseasesAcetylcholine Release InhibitorsBotulinum Toxins, Type ADysphoniaDystoniaSegmental dystoniaSpasmodic dysphoniaSpeech-language disorder

Identifiers

PMID28651822
PMCPMC5931712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.