ArticlePsychological medicine2018
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents.European child & adolescent psychiatry · 2026Article
- Identifying Distinct Tourette Disorder Subtypes using Clinical Data.medRxiv : the preprint server for health sciences · 2025Article
- Subtypes of tic disorders in children and adolescents: based on clinical characteristics.BMC pediatrics · 2025Article
- Addressing co-occurring conditions in behavioural therapy for tic disorders: a review and guideline.European child & adolescent psychiatry · 2024Review
- Advances in Clustering and Classification of Tic Disorders: A Systematic Review.Neuropsychiatric disease and treatment · 2024Review
- Prevalence and correlates of hoarding behavior and hoarding disorder in children and adolescents.European child & adolescent psychiatry · 2022Article
- Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population.World journal of psychiatry · 2022Article
- Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles.Journal of clinical medicine · 2022Article
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.European child & adolescent psychiatry · 2022Review
- Elevated levels of hoarding in ADHD: A special link with inattention.Journal of psychiatric research · 2022Article
- The Behavioral and Emotional Profile of Pediatric Tourette Syndrome Based on CBCL in a Chinese Sample.Frontiers in psychiatry · 2022Article
- Genetics of obsessive-compulsive disorder.Psychological medicine · 2021Review
- A dimensional perspective on the genetics of obsessive-compulsive disorder.Translational psychiatry · 2021Review
- A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021Review
- Challenges in the Diagnosis and Assessment in Patients with Tourette Syndrome and Comorbid Obsessive-Compulsive Disorder.Neuropsychiatric disease and treatment · 2021Review
- Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis.Frontiers in genetics · 2021Article
- Alterations in the Nervous System and Gut Microbiota afterInternational journal of molecular sciences · 2020Review
- Tourette's disorder in children and adolescents.Translational pediatrics · 2020Review
- Deep brain stimulation for Tourette's syndrome.Translational neurodegeneration · 2020Review
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20 authors at 14 institutions in 3 countries.
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Abstract
backgroundThe unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families.
methodOCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class analyses (LCA) of the resulting OCD and ADHD factor sum scores jointly; heritability and clinical relevance of the resulting factors and classes were assessed.
resultsEFA yielded a 2-factor model for ADHD and an 8-factor model for OCD. Both ADHD factors (inattentive and hyperactive/impulsive symptoms) were genetically related to TS, ADHD, and OCD. The doubts, contamination, need for sameness, and superstitions factors were genetically related to OCD, but not ADHD or TS; symmetry/exactness and fear-of-harm were associated with TS and OCD while hoarding was associated with ADHD and OCD. In contrast, aggressive urges were genetically associated with TS, OCD, and ADHD. LCA revealed a three-class solution: few OCD/ADHD symptoms (LC1), OCD & ADHD symptoms (LC2), and symmetry/exactness, hoarding, and ADHD symptoms (LC3). LC2 had the highest psychiatric comorbidity rates (⩾50% for all disorders).
conclusionsSymmetry/exactness, aggressive urges, fear-of-harm, and hoarding show complex genetic relationships with TS, OCD, and ADHD, and, rather than being specific subtypes of OCD, transcend traditional diagnostic boundaries, perhaps representing an underlying vulnerability (e.g. failure of top-down cognitive control) common to all three disorders.
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