Trial reportTrials2017
The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial.
Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02361944 (Risk of Oxygen During Cardiac Surgery), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk of Oxygen During Cardiac Surgery (ROCS) Trial
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial.Journal of the American Heart Association · 2025Trial
- Intraoperative Oxygen Concentration and Neurocognition after Cardiac Surgery.Anesthesiology · 2021Trial
- Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.Circulation research · 2024Article
- Perioperative Acute Kidney Injury: Implications, Approach, Prevention.Advances in anesthesia · 2023Review
- Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine.Nature reviews. Cardiology · 2023Review
- Review
- Hyperoxemia During Cardiac Surgery Is Associated With Postoperative Pulmonary Complications.Critical care explorations · 2023Article
- Intraoperative Oxygen Practices in Cardiac Surgery: A National Survey.Journal of cardiothoracic and vascular anesthesia · 2022Article
- Year in Review 2021: Noteworthy Literature in Cardiothoracic Anesthesia.Seminars in cardiothoracic and vascular anesthesia · 2022Review
- Hyperoxia and Acute Kidney Injury: A Tale of Oxygen and the Kidney.Seminars in nephrology · 2022Review
- Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.Anesthesiology · 2020Article
- Routine practice in mechanical ventilation in cardiac surgery in Italy.Journal of thoracic disease · 2019Article
- Mechanical ventilation management during cardiothoracic surgery: an open challenge.Annals of translational medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnesthesiologists administer excess supplemental oxygen (hyper-oxygenation) to patients during surgery to avoid hypoxia. Hyper-oxygenation, however, may increase the generation of reactive oxygen species and cause oxidative damage. In cardiac surgery, increased oxidative damage has been associated with postoperative kidney and brain injury. We hypothesize that maintenance of normoxia during cardiac surgery (physiologic oxygenation) decreases kidney injury and oxidative damage compared to hyper-oxygenation. METHODS/
designThe Risk of Oxygen during Cardiac Surgery (ROCS) trial will randomly assign 200 cardiac surgery patients to receive physiologic oxygenation, defined as the lowest fraction of inspired oxygen (FIO DISCUSSION: The ROCS trial will test the hypothesis that intraoperative physiologic oxygenation decreases oxidative damage and organ injury compared to hyper-oxygenation in patients undergoing cardiac surgery.
trial registrationClinicalTrials.gov, ID: NCT02361944 . Registered on the 30th of January 2015.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.