ArticleCerebral cortex (New York, N.Y. : 1991)2018
Alternative RNA Splicing Associated With Mammalian Neuronal Differentiation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons.Open biology · 2025Article
- Cell-Type-Specific Splicing of Transcription Regulators andThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell-type-specific splicing of transcription regulators andbioRxiv : the preprint server for biology · 2024Article
- Cortexa: a comprehensive resource for studying gene expression and alternative splicing in the murine brain.BMC bioinformatics · 2024Article
- Characterization of alternative splicing during mammalian brain development reveals the extent of isoform diversity and potential effects on protein structural changes.Biology open · 2024Article
- The emerging significance of splicing in vertebrate development.Development (Cambridge, England) · 2022Review
- EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation.Nucleic acids research · 2022Article
- Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis.Development (Cambridge, England) · 2022Article
- Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes.BMC genomics · 2022Article
- Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.Scientific reports · 2021Article
- Comprehensive Analysis of Prognostic Alternative Splicing Signature Reveals Recurrence Predictor for Papillary Thyroid Cancer.Frontiers in oncology · 2021Article
- STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.Nature communications · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Alternative pre-mRNA splicing (AS) produces multiple isoforms of mRNAs and proteins from a single gene. It is most prevalent in the mammalian brain and is thought to contribute to the formation and/or maintenance of functional complexity of the brain. Increasing evidence has documented the significant changes of AS between different regions or different developmental stages of the brain, however, the dynamics of AS and the possible function of it during neural progenitor cell (NPC) differentiation is less well known. Here, using purified NPCs and their progeny neurons isolated from the embryonic mouse cerebral cortex, we characterized the global differences of AS events between the 2 cell types by deep sequencing. The sequencing results revealed cell type-specific AS in NPCs and neurons that are important for distinct functions pertinent to the corresponding cell type. Our data may serve as a resource useful for further understanding how AS contributes to molecular regulations in NPCs and neurons during cortical development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.