Evidence map›Paper›PMID 28651306›Full record

ArticleGut and liver2017

Heme Oxygenase-1 Induction and Anti-inflammatory Actions of

Kyu-Hyun Han, Jong-Min Park, Migyeong Jeong, Young-Min Han, Eun-Jin Go, Juyeon Park, Hocheol Kim, Jae Gab Han, Oran Kwon, Ki Baik Hahm

Open access · diamondAbstract read
In one paragraph

Article in Gut and liver, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  5. Article
  6. Atractylone in theMolecules (Basel, Switzerland) · 2023
    Article
  7. An optimized herbal medicine containingJournal of traditional and complementary medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kyu-Hyun HanDigestive Disease Center, CHA University Bundang Medical Center, Seongnam, Korea.
Jong-Min ParkCHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seongnam, Korea.
Migyeong JeongCHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seongnam, Korea.
Young-Min HanCHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seongnam, Korea.
Eun-Jin GoCHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seongnam, Korea.
Juyeon ParkKorea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Inc., Seoul, Korea.
Hocheol KimDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
Jae Gab HanDepartment of Health Food Research & Development, Daesang Corp., Icheon, Korea.
Oran KwonDepartment of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
Ki Baik HahmDigestive Disease Center, CHA University Bundang Medical Center, Seongnam, Korea.
CHA University · KRCHA University Bundang Medical Center · KREwha Womans University · KRKorea Institute of Science and Technology · KRKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsIn inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of

methodsMurine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration.

results

conclusionsBecause the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be considered natural agents that can prevent IBD relapse.

Indexed as

PhytotherapyAnimalsAnti-Inflammatory Agents, Non-SteroidalAtractylodesColitisCyclooxygenase 2Dextran SulfateEnzyme InductionHeme Oxygenase-1Inflammation MediatorsLipopolysaccharidesMaleMembrane ProteinsMiceMice, Inbred C57BLPlant ExtractsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2Dextran SulfateHeme Oxygenase-1Hmox1 protein, mouseInflammation MediatorsLipopolysaccharidesMembrane ProteinsPlant ExtractsPtgs2 protein, mouseSulfasalazineTumor Necrosis Factor-alphaAtractylodes macrocephalaInflammationInflammatory bowel diseaseRegenerationTaraxacum herba

Identifiers

PMID28651306
PMCPMC5593328
OpenAlexW2683927730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.