ArticlePsychiatry research2017
A 20-Year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia.
Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- Links between trauma and psychotic symptoms: Integrating cognitive behavioural and neuropsychoanalytic models of psychosis.Psychology and psychotherapy · 2026Review
- Impact of treatment with long‑acting injectable antipsychotics on hospitalization and relapse rates in schizophrenia spectrum disorders: a 3‑year follow-up mirror‑image study.Therapeutic advances in psychopharmacology · 2026Article
- Long-term mortality and associated factors in first episode psychosis: a 25-year follow-up study.Psychological medicine · 2025Article
- Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2025Review
- Effectiveness of antipsychotic medication in patients with schizophrenia in a real world retrospective observational study in Ethiopia.Scientific reports · 2025Observational
- Multidimensional outcome of first-episode psychosis: a network analysis.Psychological medicine · 2025Article
- The Association Between Antipsychotics and Bone Fragility: An Updated Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- The pharmacological treatment of schizophrenia: How far have we come?PCN reports : psychiatry and clinical neurosciences · 2022Review
- Identifying subgroups based on self-assessment of ability in patients with schizophrenia and its relationship with vocational outcomes.Hong Kong journal of occupational therapy : HKJOT · 2022Article
- Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness.World journal of psychiatry · 2022Article
- Discontinuing Antipsychotic Medication After Remission from First-Episode Psychosis: A Survey of Psychiatrists' Attitudes in Taiwan.Neuropsychiatric disease and treatment · 2022Article
- Long-term Continuity of Antipsychotic Treatment for Schizophrenia: A Nationwide Study.Schizophrenia bulletin · 2021Article
- The Work Ability of People with Mental Illnesses: A Conceptual Analysis.International journal of environmental research and public health · 2021Review
- A Real-World Observation of Antipsychotic Effects on Brain Volumes and Intrinsic Brain Activity in Schizophrenia.Frontiers in neuroscience · 2021Article
- Challenging the Minimum Effective Antipsychotic Dose During Maintenance: Implications From 10-Year Follow-Up of First Episode Psychosis.Frontiers in psychiatry · 2021Article
- Using Open Questions to Understand 650 People's Experiences With Antipsychotic Drugs.Schizophrenia bulletin · 2020Article
- Achieving the Lowest Effective Antipsychotic Dose for Patients with Remitted Psychosis: A Proposed Guided Dose-Reduction Algorithm.CNS drugs · 2020Review
- Five Year Outcomes of Tapering Antipsychotic Drug Doses in a Community Mental Health Center.Community mental health journal · 2018Article
- Long-term antipsychotic treatment of schizophrenia: does it help or hurt over a 20-year period?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To assess the long-term effectiveness of antipsychotic medications in facilitating work functioning in patients with schizophrenia we conducted longitudinal multifollowup research on 139 initially psychotic patients. The 70 patients with schizophrenia and 69 initially psychotic mood disordered control patients were followed up 6 times over 20 years. We compared the influence on work functioning of patients with schizophrenia continuously prescribed antipsychotics with patients with schizophrenia not prescribed antipsychotics, using statistical controls for inter-subject differences. While antipsychotics reduce or eliminate flagrant psychosis for most patients with schizophrenia at acute hospitalizations, four years later and continually until the 20 year followups, patients with schizophrenia not prescribed antipsychotics had significantly better work functioning. The work performance of the patients who were continuously prescribed antipsychotics was at a low rate and did not improve over time. Multiple other factors also interfere with work functioning. The data suggest that some patients with schizophrenia not prescribed antipsychotics for prolonged periods can function relatively well. Multiple other factors are associated with poor post-hospital work performance. The longitudinal data raise questions about prolonged treatment of schizophrenia with antipsychotic medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.