Evidence map›Paper›PMID 28651098›Full record

SynthesisJournal of psychiatric research2017

An interoceptive model of bulimia nervosa: A neurobiological systematic review.

Megan Klabunde, Danielle Collado, Cara Bohon

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Journal of psychiatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. There is no such thing as interoception.Frontiers in psychology · 2025
    Article
  10. Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The role of interoception in the overlap between eating disorders and autism: Methodological considerations.European eating disorders review : the journal of the Eating Disorders Association · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan KlabundeDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States. Electronic address: mklabund@stanford.edu.
Danielle ColladoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.
Cara BohonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.
Stanford University · US

Funding

Neurochemical and functional neuroimaging of negative and positive valence systems in binge eatingK23MH106794 · NIMH · STANFORD UNIVERSITY · PI BOHON, CARA · 2015 to 2019
$894k
NIMH NIH HHS K23 MH106794
6 · The paper itself

Abstract

The objective of our study was to examine the neurobiological support for an interoceptive sensory processing model of bulimia nervosa (BN). To do so, we conducted a systematic review of interoceptive sensory processing in BN, using the PRISMA guidelines. We searched PsychInfo, Pubmed, and Web of Knowledge databases to identify biological and behavioral studies that examine interoceptive detection in BN. After screening 390 articles for inclusion and conducting a quality assessment of articles that met inclusion criteria, we reviewed 41 articles. We found that global interoceptive sensory processing deficits may be present in BN. Specifically there is evidence of abnormal brain function, structure and connectivity in the interoceptive neural network, in addition to gastric and pain processing disturbances. These results suggest that there may be a neurobiological basis for global interoceptive sensory processing deficits in BN that remain after recovery. Data from taste and heart beat detection studies were inconclusive; some studies suggest interoceptive disturbances in these sensory domains. Discrepancies in findings appear to be due to methodological differences. In conclusion, interoceptive sensory processing deficits may directly contribute to and explain a variety of symptoms present in those with BN. Further examination of interoceptive sensory processing deficits could inform the development of treatments for those with BN.

Indexed as

Models, TheoreticalBulimia NervosaHumansInteroceptionBulimia nervosaGastric distentionHeartbeatInteroceptionPainTaste

Identifiers

PMID28651098
PMCPMC6026544
OpenAlexW2710070380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.