Evidence map›Paper›PMID 28651015›Full record

ArticlePloS one2017

Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat.

Mingliang Li, Yingbo Dai, Jun Lei, Jin Tang, Yihong Zhou, Bing Xia, Yang Xia, Guangming Yin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingliang LiDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yingbo DaiDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jun LeiDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jin TangDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yihong ZhouDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Bing XiaDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yang XiaDepartment of Biochemistry and Molecular Biology, The University of Texas-Houston Medical School, Houston, Texas, United States of America.
Guangming YinDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-3247-2937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsChronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat. MATERIALS AND

methodsWistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established rat models and detected a series of indicators. All data were analyzed statistically. P<0.05 was considered statistically significant.

resultsCompared with the control group, levels of adenosine increased significantly in the allograft transplantation group, in which acute rejection was induced (P<0.05). Progressive allograft fibrosis as well as collagen deposition were observed.

conclusionsThese findings suggested that level of adenosine was upregulated in acute rejection after kidney allograft transplantation in rat. Acute rejection may promote renal allograft fibrosis via the adenosine signaling pathways.

Indexed as

Acute DiseaseAdenosineAllograftsAnimalsCollagenFibrosisGraft RejectionIsograftsKidneyKidney TransplantationRatsRats, Sprague-DawleyRats, WistarAdenosineCollagen

Identifiers

PMID28651015
PMCPMC5484506

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.