ArticlePloS one2017
Transcriptomic analysis to uncover genes affecting cold resistance in the Chinese honey bee (Apis cerana cerana).
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Evolution of the α-Glucosidase Gene Family in Apoidea.Ecology and evolution · 2026Article
- Bacterial-archaeal co-occurrence in honey bee gut microbiomes across host species and management regimes.PloS one · 2026Article
- Winter Temperature Affects Fatty Acid Composition and Gene Expression, but Not Fat Content and Survival in a Northern Population of a Range-Expanding Spider.Ecology and evolution · 2025Article
- Identification of key genes associated with overwintering in Histia rhodope larva using gene co-expression network analysis.BMC genomics · 2025Article
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- High abundance of lactobacilli in the gut microbiome of honey bees during winter.Scientific reports · 2025Article
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- Alternative Splicing and Alternative Polyadenylation-Regulated Cold Stress Response ofInsects · 2024Article
- Based proteomics analyses reveal response mechanisms of Apis mellifera (Hymenoptera: Apidae) against the heat stress.Journal of insect science (Online) · 2024Article
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- Genomic selection pressure discovery using site-frequency spectrum and reduced local variability statistics in Pakistani Dera-Din-Panah goat.Tropical animal health and production · 2023Article
- The impact of geography and climate on the population structure and local adaptation in a wild bee.Evolutionary applications · 2023Article
- A key gene for the climatic adaptation of Apis cerana populations in China according to selective sweep analysis.BMC genomics · 2023Article
- Signatures of Positive Selection in the Genome ofLife (Basel, Switzerland) · 2022Article
- Geometric morphology and population genomics provide insights into the adaptive evolution of Apis cerana in Changbai Mountain.BMC genomics · 2022Article
- Identification of quantitative trait loci associated with calmness and gentleness in honey bees using whole-genome sequences.Animal genetics · 2021Article
- Article
- Genomic analysis of Asian honeybee populations in China reveals evolutionary relationships and adaptation to abiotic stress.Ecology and evolution · 2020Article
- Transcriptomic analysis to elucidate the response of honeybees (Hymenoptera: Apidae) to amitraz treatment.PloS one · 2020Article
- Long-Distance Transportation Causes Temperature Stress in the Honey Bee, Apis mellifera (Hymenoptera: Apidae).Environmental entomology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological activity and geographical distribution of honey bees is strongly temperature-dependent, due to their ectothermic physiology. In China, the endemic Apis cerana cerana exhibits stronger cold hardiness than Western honey bees, making the former species important pollinators of winter-flowering plants. Although studies have examined behavioral and physiological mechanisms underlying cold resistance in bees, data are scarce regarding the exact molecular mechanisms. Here, we investigated gene expression in A. c. cerana under two temperature treatments, using transcriptomic analysis to identify differentially expressed genes (DEGs) and relevant biological processes, respectively. Across the temperature treatments, 501 DEGs were identified. A gene ontology analysis showed that DEGs were enriched in pathways related to sugar and amino acid biosynthesis and metabolism, as well as calcium ion channel activity. Additionally, heat shock proteins, zinc finger proteins, and serine/threonine-protein kinases were differentially expressed between the two treatments. The results of this study provide a general digital expression profile of thermoregulation genes responding to cold hardiness in A. c. cerana. Our data should prove valuable for future research on cold tolerance mechanisms in insects, and may be beneficial in breeding efforts to improve bee hardiness.
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