ArticleNature communications2017
Prevalence of sexual dimorphism in mammalian phenotypic traits.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 5 of them syntheses that pooled it.
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174citing papers in PubMed, 5 pooled it
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Who cites it
174 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.Biology of sex differences · 2023Pooled it
- Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications.eLife · 2020Pooled it
- Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis.PLoS biology · 2019Pooled it
- A systematic review of research investigating the physiological and psychological effects of combining Ginkgo biloba and Panax ginseng into a single treatment in humans: Implications for research design and analysis.Brain and behavior · 2019Pooled it
- Sex differences in cardiovascular epigenetics-a systematic review.Biology of sex differences · 2018Pooled it
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Sex differences in renal acid-base regulation.Current opinion in nephrology and hypertension · 2026Review
- Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice.bioRxiv : the preprint server for biology · 2026Article
- Genetic regulation of fasting-induced longevity effects.Genetics · 2026Article
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- Dynamic transcriptome analysis highlights collagen-integrin-mediated extracellular matrix remodeling underlying sexual dimorphism in the amplexus muscle of Bufo gargarizans.Biology of sex differences · 2026Article
- Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- New approaches to meta-analyze differences in skewness, kurtosis, and correlation.PLoS biology · 2026Article
- Quantitative dissection of sexual dimorphism in mice through Y-linked gene knockouts and multivariate phenotyping.Scientific reports · 2026Article
- International Mouse Phenotyping Consortium Portal: facilitating investigation of gene function and providing insights into human disease.Nucleic acids research · 2026Article
- Addressing cultural and knowledge barriers to enable preclinical sex inclusive research.eLife · 2025Article
- A visualization tool for individual gene expression profiles among males and females in GTEx tissues.Biology of sex differences · 2025Article
- International Mouse Phenotyping Consortium: Investigating gene function and providing insights into human disease.bioRxiv : the preprint server for biology · 2025Article
- ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets.Communications biology · 2025Article
- Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
44 authors.
Natasha A KarpMouse Informatics Group, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Jeremy MasonEuropean Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0002-2796-5123
Arthur L BeaudetHuman and Molecular Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.
Yoav BenjaminiDepartment of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Lynette BowerMouse Biology Program, University of California, 2795 Second Street, Suite 400, Davis, California 95618, USA.
Robert E BraunThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
Steve D M BrownMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
Elissa J CheslerThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.ORCID 0000-0002-5642-5062
Mary E DickinsonMolecular Physiology and Biophysics, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.
Ann M FlennikenThe Centre for Phenogenomics, 25 Orde Street, Toronto, Ontario, Canada M5T 3H7.
Helmut FuchsGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg 85764, Germany.
Martin Hrabe de AngelisGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg 85764, Germany.ORCID 0000-0002-7898-2353
Xiang GaoModel Animal Research Center, Nanjing University, 12 Xuefu Road, Pukou, Nanjing, Jiangsu 210061, China.
Shiying GuoModel Animal Research Center, Nanjing University, 12 Xuefu Road, Pukou, Nanjing, Jiangsu 210061, China.
Simon GreenawayMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
Ruth HellerDepartment of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Yann HeraultCELPHEDIA, PHENOMIN, Institut Clinique de la Souris, 1 Rue Laurent Fries, Illkirch 67404, France.ORCID 0000-0001-7049-6900
Monica J JusticeThe Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Natalja KurbatovaDepartment of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Christopher J LelliottMouse Genetics Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-8087-4530
K C Kent LloydMouse Biology Program, University of California, 2795 Second Street, Suite 400, Davis, California 95618, USA.
Ann-Marie MallonMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
Judith E MankDepartment of Genetics, Evolution &Environment, University College London, Gower Street, London WC1E 6BT, UK.
Hiroshi MasuyaBioResource Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
Colin McKerlieThe Centre for Phenogenomics, 25 Orde Street, Toronto, Ontario, Canada M5T 3H7.ORCID 0000-0002-2232-0967
Terrence F MeehanEuropean Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Richard F MottGenetics Institute, University College London, Gower Street, London WC1E 6BT, UK.
Stephen A MurrayThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
Helen ParkinsonEuropean Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Ramiro Ramirez-SolisMouse Genetics Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Luis SantosMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
John R SeavittHuman and Molecular Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.
Damian SmedleyClinical Pharmacology, Queen Mary University of London, Gower Street, London WC1E 6BT, UK.
Tania SorgCELPHEDIA, PHENOMIN, Institut Clinique de la Souris, 1 Rue Laurent Fries, Illkirch 67404, France.
Anneliese O SpeakMouse Genetics Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Karen P SteelMouse Genetics Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Karen L SvensonThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
International Mouse Phenotyping Consortium
Shigeharu WakanaBioResource Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.ORCID 0000-0001-8532-0924
David WestChildren's Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA.
Sara WellsMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
Henrik WesterbergMRC Harwell Institute, Harwell Campus, Harwell OX11 0RD, UK.
Shay YaacobyDepartment of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0002-2583-4170
Jacqueline K WhiteThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MThe Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)UM1OD023222 · OD · JACKSON LABORATORY · PI ROBERT E BRAUN, Stephen A Murray · 2016 to 2026
$47.2MKOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7MUCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2MHigh Throughput Production and Cryopreservation of Knockout MiceU42OD011185 · OD · JACKSON LABORATORY · PI MURRAY, STEPHEN A, TAFT, ROBERT A · 2012 to 2015
$17.9MMedical Research Council G0300212Medical Research Council MC_QA137918Medical Research Council MC_U142684171Medical Research Council MC_U142684172Medical Research Council MC_UP_1502/3Medical Research Council MR/N012119/1NCI NIH HHS P30 CA034196NHGRI NIH HHS UM1 HG006348NIH HHS U42 OD011185NIH HHS U42 OD012210NIH HHS UM1 OD023221NIH HHS UM1 OD023222
Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Indexed as
Quantitative Trait, HeritableSex CharacteristicsAnimalsBody WeightFemaleGenes, ModifierGenotypeMammalsMicePhenotype
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.