ReviewJournal of dental research2017
Current and Emerging Treatments for Postsurgical Cleft Lip Scarring: Effectiveness and Mechanisms.
Review in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Observational
- Fractional CO₂ Laser (SCAR3 Scanner) for a Hypertrophic Retracting Cleft Lip Scar: A Case Report.The American journal of case reports · 2026Article
- Presentation, Management, and Outcomes of Pathologic Scars Within a Pediatric Otolaryngology Practice.The Laryngoscope · 2024Article
- Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing.Stem cell research & therapy · 2023Review
- Assessing the Impact of Transcutaneous Maxillary Distraction Osteogenesis on Pharyngeal Airway Volume in Children with Cleft Lip and Palate: A 3D Evaluation Study.Journal of personalized medicine · 2023Article
- The comparison of biomechanical effects of the conventional and bone-borne palatal expanders on late adolescence with unilateral cleft palate: a 3-dimensional finite element analysis.BMC oral health · 2022Article
- Article
- RvD1International journal of molecular sciences · 2022Article
- Orodispersible hyaluronic acid film delivery for oral wound healing in rats.Journal of dental sciences · 2022Article
- Effect of niche components on masseter satellite cell differentiation on fibrin coatings.European journal of oral sciences · 2022Article
- Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip.PloS one · 2022Article
- Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair.Frontiers in immunology · 2022Article
- Visual perception of repaired cleft lip scarring face associated with different malocclusions via eye-tracking.Journal of dental research, dental clinics, dental prospects · 2022Article
- Evaluating the Expression of Candidate Homeobox Genes and Their Role in Local-Site Inflammation in Mucosal Tissue Obtained from Children with Non-Syndromic Cleft Lip and Palate.Journal of personalized medicine · 2021Article
- Profiling and Characterization of Localized Cytokine Response in Congenital Cleft Affected Lip Tissue.Life (Basel, Switzerland) · 2021Article
- Revisional Techniques for Secondary Cleft Lip Deformities.Seminars in plastic surgery · 2021Review
- Endogenous Mechanisms of Craniomaxillofacial Repair: Toward Novel Regenerative Therapies.Frontiers in oral health · 2021Review
- Visual facial perception of postsurgical cleft lip scarring assessed by laypeople via eye-tracking.Journal of orthodontic science · 2021Article
- Characterization of Cytokines and Proliferation Marker Ki67 in Cleft Affected Lip Tissue.Medicina (Kaunas, Lithuania) · 2019Article
- The Spectrum of Scarring in Craniofacial Wound Repair.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cleft lip with or without cleft palate is the most common congenital malformation of the head and the third-most common birth defect. Surgical repair of the lip is the only treatment and is usually performed during the first year of life. Hypertrophic scar (HTS) formation is a frequent postoperative complication that impairs soft tissue form, function, or movement. Multiple lip revision operations are often required throughout childhood, attempting to optimize aesthetics and function. The mechanisms guiding HTS formation are multifactorial and complex. HTS is the result of dysregulated wound healing, where excessive collagen and extracellular matrix proteins are deposited within the wound area, resulting in persistent inflammation and resultant fibrosis. Many studies support the contribution of dysregulated, exaggerated inflammation in scar formation. Fibrosis and scarring result from chronic inflammation that interrupts tissue remodeling in normal wound healing. Failure of active resolution of inflammation pathways has been implicated. The management of HTS has been challenging for clinicians, since current therapies are minimally effective. Emerging evidence that specialized proresolving mediators of inflammation accelerate wound healing by preventing chronic inflammation and allowing natural uninterrupted tissue remodeling suggests new therapeutic opportunities in the prevention and management of HTS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.