Evidence map›Paper›PMID 28650628›Full record

ArticleACS chemical neuroscience2017

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood-Brain Barrier.

Renske M Raaphorst, Gert Luurtsema, Robert C Schuit, Esther J M Kooijman, Philip H Elsinga, Adriaan A Lammertsma, Albert D Windhorst

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  2. Review
  3. Molecules (Basel, Switzerland) · 2022
    Review
  4. Review
  5. Dealing with PET radiometabolites.EJNMMI research · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Renske M RaaphorstDepartment of Radiology & Nuclear Medicine, VU University Medical Center , 1081 HV Amsterdam, The Netherlands.ORCID 0000-0003-3975-3686
Gert LuurtsemaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen , 9712 CP Groningen, The Netherlands.
Robert C SchuitDepartment of Radiology & Nuclear Medicine, VU University Medical Center , 1081 HV Amsterdam, The Netherlands.
Esther J M KooijmanDepartment of Radiology & Nuclear Medicine, VU University Medical Center , 1081 HV Amsterdam, The Netherlands.
Philip H ElsingaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen , 9712 CP Groningen, The Netherlands.
Adriaan A LammertsmaDepartment of Radiology & Nuclear Medicine, VU University Medical Center , 1081 HV Amsterdam, The Netherlands.
Albert D WindhorstDepartment of Radiology & Nuclear Medicine, VU University Medical Center , 1081 HV Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P-glycoprotein is an efflux transporter located in the blood-brain barrier. (R)-[

Indexed as

Positron-Emission TomographyRadiopharmaceuticalsAnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Blood-Brain BarrierCentral Nervous System AgentsDrug Evaluation, PreclinicalDrug StabilityMaleMice, KnockoutMolecular StructureQuinolinesRats, WistarAbcg2 protein, mouseATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Central Nervous System Agentsmultidrug resistance protein 3QuinolinesRadiopharmaceuticalstariquidarVerapamil18FABC transportersBCRPblood−brain barrierP-gppositron emission tomographyverapamil

Identifiers

PMID28650628
PMCPMC5609126
OpenAlexW2720035343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.