Evidence map›Paper›PMID 28650469›Full record

ArticleOncogene2017

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

S E Conduit, V Ramaswamy, M Remke, D N Watkins, B J Wainwright, M D Taylor, C A Mitchell, J M Dyson

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Regulation of INPP5E in Ciliogenesis, Development, and Disease.International journal of biological sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Phosphoinositides in New Spaces.Cold Spring Harbor perspectives in biology · 2023
    Review
  7. Rediscovering Primary Cilia in Pancreatic Islets.Diabetes & metabolism journal · 2023
    Review
  8. Group-specific cellular metabolism in Medulloblastoma.Journal of translational medicine · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. INPP5E and Coordination of Signaling Networks in Cilia.Frontiers in molecular biosciences · 2022
    Review
  14. Article
  15. Cilia signaling and obesity.Seminars in cell & developmental biology · 2021
    Review
  16. Article
  17. Article
  18. Down-Regulation ofFrontiers in neurology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

S E ConduitDepartment of Biochemistry and Molecular Biology, Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
V RamaswamyDivision of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6557-895X
M RemkeThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
D N WatkinsThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
B J WainwrightDivision of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
M D TaylorThe Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
C A MitchellDepartment of Biochemistry and Molecular Biology, Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
J M DysonDepartment of Biochemistry and Molecular Biology, Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Hospital for Sick Children · CAMonash University · AUGarvan Institute of Medical Research · AUThe University of Queensland · AU

Funding

Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4M
Medulloblastoma and MetastasesR01CA148699 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2010 to 2014
$2.4M
NCI NIH HHS R01 CA148699NCI NIH HHS R01 CA159859
6 · The paper itself

Abstract

Sonic Hedgehog (SHH) signaling at primary cilia drives the proliferation and progression of a subset of medulloblastomas, the most common malignant paediatric brain tumor. Severe side effects associated with conventional treatments and resistance to targeted therapies has led to the need for new strategies. SHH signaling is dependent on primary cilia for signal transduction suggesting the potential for cilia destabilizing mechanisms as a therapeutic target. INPP5E is an inositol polyphosphate 5-phosphatase that hydrolyses PtdIns(4,5)P

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorCell ProliferationCiliaDisease Models, AnimalGlycogen Synthase Kinase 3 betaHedgehog ProteinsHumansMedulloblastomaMiceOncogene Protein v-aktPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoinositide 5-PhosphatasesPhosphoric Monoester HydrolasesGlycogen Synthase Kinase 3 betaGPR161 protein, mouseHedgehog ProteinsOncogene Protein v-aktphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoinositide 5-PhosphatasesPhosphoric Monoester HydrolasesReceptors, G-Protein-Coupled

Identifiers

PMID28650469
OpenAlexW2673715476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.