ArticleCell cycle (Georgetown, Tex.)2017
Interrogating cell division errors using random and chromosome-specific missegregation approaches.
Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.Frontiers in pharmacology · 2026Article
- Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities.Journal of molecular cell biology · 2024Review
- Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation.Methods in cell biology · 2024Article
- Satellite DNAs and human sex chromosome variation.Seminars in cell & developmental biology · 2022Review
- Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer.Journal of breast cancer · 2019Article
- Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.Nature genetics · 2019Article
- Induced aneuploidy in neural stem cells triggers a delayed stress response and impairs adult life span in flies.PLoS biology · 2019Article
- Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability.Molecular biology of the cell · 2018Article
- Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.Trends in cell biology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Accurate segregation of the duplicated genome in mitosis is essential for maintaining genetic stability. Errors in this process can cause numerical and/or structural chromosome abnormalities - hallmark genomic features commonly associated with both tumorigenesis and developmental disorders. A cell-based approach was recently developed permitting inducible missegregation of the human Y chromosome by selectively disrupting kinetochore assembly onto the Y centromere. Although this strategy initially requires several steps of genetic manipulation, it is easy to use, highly efficient and specific for the Y without affecting the autosomes or the X, and does not require cell cycle synchronization or mitotic perturbation. Here we describe currently available tools for studying chromosome segregation errors, aneuploidy, and micronuclei, as well as discuss how the Y-specific missegregation system has been used to elucidate how chromosomal micronucleation can trigger a class of extensive rearrangements termed chromothripsis. The combinatorial use of these different tools will allow unresolved aspects of cell division defects and chromosomal instability to be experimentally explored.
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